Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 13، دوره 19، شماره 9، آذر 2016، صفحه 1010-1015 اصل مقاله (1.01 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2016.7602 | ||
| نویسندگان | ||
| Ling Zhang1؛ Ke Chen1؛ Tiantian Li1؛ Hao He2؛ Li Hou1؛ Xiaoyong Wu3؛ Yanping Sun2؛ Lei Zheng2؛ Zhixiong Chen4؛ Bei Qin2؛ Xinyi Chen1؛ Shaodan Tian* 1 | ||
| 1Dongzhimen Hosp. Beijing University of Chinese Medicine. No. 5 Haiyuncang, Dongcheng District, Beijing, China | ||
| 2School of Pharmacy, Xi’an Medical College, Shanxi 710021, China | ||
| 3No. 1 Hospital Affiliated to Guiyang College of TCM, GuiYang 550001, China | ||
| 4No. 1 Hospital Affiliated to Guangzhou University of Chinese Medicine, Guangzhou 510405, China | ||
| چکیده | ||
| Objective(s): The main objective of this study was to investigate the variations of β-endorphin (β-EP), vasoactive intestinal peptide (VIP), serotonin (5-HT) and norepinephrine (NE) of immune thrombocytopenia (ITP) mice as well as the regulatory mechanism of prednison. Materials and Methods: Sixty BALB/c mice were randomly divided into control group, model group and prednison intervention group. ITP mice model was duplicated by injecting with glycoprotein-antiplatelet serum (GP-APS) except in control group. After ITP disease model was successful established, prednison was used in prednison intervention group. The β-EP, VIP, 5-HT and NE contents of ITP mice were detected by enzyme linked immunosorbent assay (ELISA). Results:Compared with the values in control group, the detection values of VIP and 5-HT in model group declined, while the detection values of β-EP and NE increased. Compared with prednison intervention group, the detection values of VIP and 5-HT in model group increased, while the detection values of β-EP and NE showed no significant change. Conclusion: In this study, the β-EP, VIP, 5-HT and NE contents in ITP mice injected with GP-APS were changed by prednison. It shows that prednison as the first-line therapy for ITP with effective hemostasis function is likely to increasing the contents of VIP and 5-HT. These results suggest the therapeutic value of prednison for the treatment of ITP. | ||
| کلیدواژهها | ||
| Immune thrombocytopenia؛ Mice؛ Norepinephrine VIP؛ β-EP؛ 5-HT | ||
| مراجع | ||
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