Zhang, Ling, Chen, Ke, Li, Tiantian, He, Hao, Hou, Li, Wu, Xiaoyong, Sun, Yanping, Zheng, Lei, Chen, Zhixiong, Qin, Bei, Chen, Xinyi, Tian, Shaodan. (1395). Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia. , 19(9), 1010-1015. doi: 10.22038/ijbms.2016.7602
Ling Zhang; Ke Chen; Tiantian Li; Hao He; Li Hou; Xiaoyong Wu; Yanping Sun; Lei Zheng; Zhixiong Chen; Bei Qin; Xinyi Chen; Shaodan Tian. "Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia". , 19, 9, 1395, 1010-1015. doi: 10.22038/ijbms.2016.7602
Zhang, Ling, Chen, Ke, Li, Tiantian, He, Hao, Hou, Li, Wu, Xiaoyong, Sun, Yanping, Zheng, Lei, Chen, Zhixiong, Qin, Bei, Chen, Xinyi, Tian, Shaodan. (1395). 'Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia', , 19(9), pp. 1010-1015. doi: 10.22038/ijbms.2016.7602
Zhang, Ling, Chen, Ke, Li, Tiantian, He, Hao, Hou, Li, Wu, Xiaoyong, Sun, Yanping, Zheng, Lei, Chen, Zhixiong, Qin, Bei, Chen, Xinyi, Tian, Shaodan. Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia. , 1395; 19(9): 1010-1015. doi: 10.22038/ijbms.2016.7602

Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia

Iranian Journal of Basic Medical Sciences
مقاله 13، دوره 19، شماره 9، 2016، صفحه 1010-1015    اصل مقاله (1.01 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2016.7602
نویسندگان
Ling Zhang1؛ Ke Chen1؛ Tiantian Li1؛ Hao He2؛ Li Hou1؛ Xiaoyong Wu3؛ Yanping Sun2؛ Lei Zheng2؛ Zhixiong Chen4؛ Bei Qin2؛ Xinyi Chen1؛ Shaodan Tian* 1
1Dongzhimen Hosp. Beijing University of Chinese Medicine. No. 5 Haiyuncang, Dongcheng District, Beijing, China
2School of Pharmacy, Xi’an Medical College, Shanxi 710021, China
3No. 1 Hospital Affiliated to Guiyang College of TCM, GuiYang 550001, China
4No. 1 Hospital Affiliated to Guangzhou University of Chinese Medicine, Guangzhou 510405, China
چکیده
Objective(s): The main objective of this study was to investigate the variations of β-endorphin (β-EP), vasoactive intestinal peptide (VIP), serotonin (5-HT) and norepinephrine (NE) of immune thrombocytopenia (ITP) mice as well as the regulatory mechanism of prednison.
Materials and Methods: Sixty BALB/c mice were randomly divided into control group, model group and prednison intervention group. ITP mice model was duplicated by injecting with glycoprotein-antiplatelet serum (GP-APS) except in control group. After ITP disease model was successful established, prednison was used in prednison intervention group. The β-EP, VIP, 5-HT and NE contents of ITP mice were detected by enzyme linked immunosorbent assay (ELISA).
Results:Compared with the values in control group, the detection values of VIP and 5-HT in model group declined, while the detection values of β-EP and NE increased. Compared with prednison intervention group, the detection values of VIP and 5-HT in model group increased, while the detection values of β-EP and NE showed no significant change.
Conclusion: In this study, the β-EP, VIP, 5-HT and NE contents in ITP mice injected with GP-APS were changed by prednison. It shows that prednison as the first-line therapy for ITP with effective hemostasis function is likely to increasing the contents of VIP and 5-HT. These results suggest the therapeutic value of prednison for the treatment of ITP.
کلیدواژه‌ها
Immune thrombocytopenia؛ Mice؛ Norepinephrine VIP؛ β-EP؛ 5-HT
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