Ayyildiz, Ali, Ayyildiz, Sema Nur, Benli, Erdal, Erdem, Havva, Cirrik, Selma, Noyan, Tevfik, Germiyanoglu, R. Cankon, Çirakoglu, Abdullah. (1395). The effect of oral and intraurethral trimetazidine use on urethral healing. , 19(9), 932-939. doi: 10.22038/ijbms.2016.7592
Ali Ayyildiz; Sema Nur Ayyildiz; Erdal Benli; Havva Erdem; Selma Cirrik; Tevfik Noyan; R. Cankon Germiyanoglu; Abdullah Çirakoglu. "The effect of oral and intraurethral trimetazidine use on urethral healing". , 19, 9, 1395, 932-939. doi: 10.22038/ijbms.2016.7592
Ayyildiz, Ali, Ayyildiz, Sema Nur, Benli, Erdal, Erdem, Havva, Cirrik, Selma, Noyan, Tevfik, Germiyanoglu, R. Cankon, Çirakoglu, Abdullah. (1395). 'The effect of oral and intraurethral trimetazidine use on urethral healing', , 19(9), pp. 932-939. doi: 10.22038/ijbms.2016.7592
Ayyildiz, Ali, Ayyildiz, Sema Nur, Benli, Erdal, Erdem, Havva, Cirrik, Selma, Noyan, Tevfik, Germiyanoglu, R. Cankon, Çirakoglu, Abdullah. The effect of oral and intraurethral trimetazidine use on urethral healing. , 1395; 19(9): 932-939. doi: 10.22038/ijbms.2016.7592

The effect of oral and intraurethral trimetazidine use on urethral healing

Iranian Journal of Basic Medical Sciences
مقاله 3، دوره 19، شماره 9، 2016، صفحه 932-939    اصل مقاله (1.36 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2016.7592
نویسندگان
Ali Ayyildiz* 1؛ Sema Nur Ayyildiz2؛ Erdal Benli1؛ Havva Erdem3؛ Selma Cirrik3؛ Tevfik Noyan2؛ R. Cankon Germiyanoglu4؛ Abdullah Çirakoglu1
1Ordu University Medical Faculty, Urology Department, Ordu, Turkey
2Ordu University Medical Faculty, Clinical Biochemistry Department, Ordu, Turkey
3Ordu University Medical Faculty, Pathology Department, Ordu, Turkey
4Ondokuz Mayıs University Medical Faculty, Urology Department, Samsun, Turkey
چکیده
Objective(s): We aimed to study the effect of trimetazidine (TMZ) on urethral wound repair.
Materials and Methods: A total of 52 male rats were used; 8 groups were formed: 1-week and 3-week control (C1,C3), sham (S1, S3), oral (OT1, OT3), and intraurethral TMZ (IUT1, IUT3) groups. Serum and urine total antioxidant capacity (TAC), total oxidant capacity (TOC), and 8-hydroxy-deoxy-guanosine (8-OHdG) were studied. Hematoxyline-Eosin was used for the histopathological study. In addition, tumor necrosis factor alpha (TNF- α), interleukin 1α, and β levels were compared across groups by an immunohistochemical method.
Results: There were significant differences between C3 and IUT3, OT3 and IUT3 with respect to serum TAC in 3-week groups (P=0.013; P =0.001). Serum TOC levels were significantly different between C3 and IUT3; S3 and OT3; and OT3 and IUT3 groups (P =0.024; P =0.019; P =0.000, respectively). Serum 8-OHdG levels were significantly different between C3 and OT3 groups (P=0.033). In the immunohistochemical examination, C1 and OT1; C1 and IUT1; and S1, S3, OT1, OT3, IUT1 groups were significantly different with respect to IL-1β staining (P=0.007; P =0.000; P=0.009), while there was a significant difference between C3 and S3 with respect to IL-1β (P =0.000).
Conclusion: TMZ increased urinary total oxidant level; while increasing serum TAC levels in the long-term. It also reduced serum TAC levels in urethral use and caused an increase in serum TOC levels with minimal effects on DNA injury and repair. No effect was detected on IL1 α and TNF, but partially reduced the effect on IL-1 β levels.
کلیدواژه‌ها
Oxidative stress؛ Trimetazidine؛ Urethral healing؛ Urethral Injury
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