Comparison of pharmacokinetic parameters of ranolazine between diabetic and non-diabetic rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 10، دوره 25، شماره 7، مهر 2022، صفحه 865-870 اصل مقاله (474.26 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2022.64391.14156 | ||
| نویسندگان | ||
| Habibeh Mashayekhi-sardoo1؛ Hossein Kamali2، 3؛ Soghra Mehri1؛ Amirhossein Sahebkar4، 5، 6؛ Mohsen Imenshahidi* 1، 7؛ Amir Hooshang Mohammadpour* 7، 8 | ||
| 1Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 4Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 5Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 6Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 7Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 8Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective(s): Diabetes mellitus (DM) affects the pharmacokinetics of drugs. Ranolazine is an antianginal drug that is prescribed in DM patients with angina. We decided to evaluate the effect of DM on the pharmacokinetics of ranolazine and its major metabolite CVT-2738 in rats. Materials and Methods: Male rats were divided into two groups: DM (induced by 55 mg/kg Streptozotocin (STZ)) and non-DM. All animals were treated with 80 mg/kg of ranolazine for 7 continuous days. The blood samples were collected immediately at 0 (prior to dosing), 1, 2, 3, 4, 8, and 12 hr after administration of the 7th dose of ranolazine. Serum ranolazine and CVT-2738 concentrations were determined using the high-performance liquid chromatography (HPLC) method. Pharmacokinetic parameters were calculated using a non-compartmental model and compared between the two groups. Results: The peak serum concentration (Cmax) and area under the curve (AUC) of ranolazine significantly decreased in DM compared with non-DM rats. DM rats showed significantly higher volumes of distribution (Vd) and clearance (CL) of ranolazine than non-DM rats. DM did not affect Ke, Tmax, and T1/2 of ranolazine. The concentration of metabolite was lower than the HPLC limit of detection (LOD). Conclusion: It was found that streptozotocin-induced DM increased Vd and CL of ranolazine, thereby decreasing the AUC of the drug. Therefore, dosage adjustment may be necessary for DM patients, which requires further clinical studies. | ||
| کلیدواژهها | ||
| Clearance؛ Diabetes mellitus؛ Pharmacokinetics؛ Ranolazine؛ Volume of distribution | ||
| مراجع | ||
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