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Yousefnia, Hassan, naderi, mojdeh, zolghadri, samaneh, Alirezapour, Behrooz, Beiki, Davood. (1396). Evaluation of the Possible Utilization of 68Ga-DOTATOC in Diagnosis of Adenocarcinoma Breast Cancer. , 6(1), 41-49. doi: 10.22038/aojnmb.2017.23695.1168
Hassan Yousefnia; mojdeh naderi; samaneh zolghadri; Behrooz Alirezapour; Davood Beiki. "Evaluation of the Possible Utilization of 68Ga-DOTATOC in Diagnosis of Adenocarcinoma Breast Cancer". , 6, 1, 1396, 41-49. doi: 10.22038/aojnmb.2017.23695.1168
Yousefnia, Hassan, naderi, mojdeh, zolghadri, samaneh, Alirezapour, Behrooz, Beiki, Davood. (1396). 'Evaluation of the Possible Utilization of 68Ga-DOTATOC in Diagnosis of Adenocarcinoma Breast Cancer', , 6(1), pp. 41-49. doi: 10.22038/aojnmb.2017.23695.1168
Yousefnia, Hassan, naderi, mojdeh, zolghadri, samaneh, Alirezapour, Behrooz, Beiki, Davood. Evaluation of the Possible Utilization of 68Ga-DOTATOC in Diagnosis of Adenocarcinoma Breast Cancer. , 1396; 6(1): 41-49. doi: 10.22038/aojnmb.2017.23695.1168

Evaluation of the Possible Utilization of 68Ga-DOTATOC in Diagnosis of Adenocarcinoma Breast Cancer

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 6، دوره 6، شماره 1، فروردین 2018، صفحه 41-49    اصل مقاله (1.15 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/aojnmb.2017.23695.1168
نویسندگان
Hassan Yousefnia* 1؛ mojdeh naderi2؛ samaneh zolghadri3؛ Behrooz Alirezapour3؛ Davood Beiki4
1Nuclear Science and Technology Research Institute (NSTRI)
2University of Zanjan , Zanjan, Iran, Postal Code: 4537138791
3nuclear science and technology research institute
4tehran university
چکیده
Objective(s): Studies have indicated advantageous properties of [DOTA-DPhe1 , Tyr3 ] octreotide (DOTATOC) in tumor models and labeling with gallium. Breast cancer is the second leading cause of cancer mortality in women, and most of these cancers are often an adenocarcinoma. Due to the importance of target to non-target ratios in the efficacy of diagnosis, the pharmacokinetic of 68Ga-DOTATOC in an adenocarcinoma breast cancer animal model was studied in this research, and the optimized time for imaging was determined. Methods: 68Ga was obtained from 68Ge/68Ga generator. The complex was prepared at optimized conditions. Radiochemical purity of the complex was checked using both HPLC and ITLC methods. Biodistribution of the complex was studied in BALB/c mice bearing adenocarcinoma breast cancer. Also, PET/CT imaging was performed up to 120 min post injection. Results: The complex was produced with radiochemical purity of greater than %98 and specific activity of about 40 GBq/mM at optimized conditions. Biodistribution of the complex was studied in BALB/c mice bearing adenocarcinoma breast cancer indicated fast blood clearance and significant uptake in the tumor. Significant tumor:blood and tumor:muscle uptake ratios were observed even at early times postinjection. PET/CT images were also confirmed the considerable accumulation of the tracer in the tumor. Conclusion: Generally, the results proved the possible application of the radiolabelled complex for the detection of the adenocarcinoma breast cancer and according to the pharmacokenitic data, the suitable time for imaging was determined as at least 30 min after injection.
کلیدواژه‌ها
Adenocarcinoma breast cancer؛ Gallium-68؛ PET/CT imaging
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