Antimalarial and cytotoxic activities of roots and fruits fractions of Astrodaucus persicus extract | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 5، دوره 20، شماره 12، اسفند 2017، صفحه 1318-1323 اصل مقاله (995.75 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2017.9554 | ||
| نویسندگان | ||
| Saied Goodarzi1؛ Mehdi Nateghpour2؛ Parina Asgharian3؛ Abbas Hadjiakhoondi1، 4؛ Narguess Yassa1، 4؛ Saeed Tavakoli4؛ Jalal Mirzaei4؛ Leila Farivar2؛ Afsaneh Motevalli Haghi2؛ Zahra Tofighi* 1، 4 | ||
| 1Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran | ||
| 2Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran | ||
| 3Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 4Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Objective(s):Astrodaucus persicus (Apiaceae) is one of the two species of this genus which grows in different parts of Iran. Roots of this plant were rich in benzodioxoles and used as food additive or salad in Iran and near countries. The aim of present study was evaluation of antimalarial and cytotoxic effects of different fractions of A. persicus fruits and roots extracts. Materials and Methods: Ripe fruits and roots of A. persicuswere extracted and fractionated by hexane, chloroform, ethyl acetate and methanol, separately. Antimalarial activities of fractions were performed based on Plasmodium berghei suppressive test in mice model and percentage of parasitemia and suppression were determined for each sample. Cytotoxicity of fruits and roots fractions were investigated against human breast adenocarcinoma (MCF-7), colorectal carcinoma (SW480) and normal (L929) cell lines by MTT assay and IC50 of them were measured. Results: Hexane fraction of roots extract (RHE) and ethyl acetate fraction of fruits extract (FEA) of A. persicus demonstrated highest parasite inhibition (73.3 and 72.3%, respectively at 500 mg/kg/day) which were significantly different from negative control group (P<0.05). In addition, RHE showed potent anticancer activities against MCF-7 (IC50 of 0.01 µg/ml), SW480 (IC50 of 0.36 µg/ml) and L929 (IC50 of 0.70 µg/ml) cell lines. Conclusion: According to the results, RHE and FEA fractions of A. persicus could be introduced as excellent choice for antimalarial drug discovery. In addition, cytotoxic activity of RHE was noticeable. | ||
| کلیدواژهها | ||
| Antimalaria؛ Apiaceae؛ Astrodaucus persicus؛ Cytotoxic؛ MTT Assay؛ Plasmodium berghei | ||
| مراجع | ||
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