Acute sleep deprivation preconditions the heart against ischemia/ reperfusion injury: the role of central GABA-A receptors | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 9، دوره 20، شماره 11، بهمن 2017، صفحه 1232-1241 اصل مقاله (1.08 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2017.9539 | ||
| نویسندگان | ||
| Hoda Parsa1؛ Alireza Imani1، 2؛ Mahdieh Faghihi1؛ Esmail Riahi1؛ Mohammad Badavi3؛ Abbas Shakoori4؛ Tayebeh Rastegar5؛ Marjan Aghajani1؛ Sulail Fatima Rajani* 6 | ||
| 1Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| 2Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran | ||
| 3Department of Physiology, School of Medicine, Ahwaz University of Medical Sciences, Ahwaz, Iran | ||
| 4Department of Genetic, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| 5Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| 6Department of Physiology, School of Medicine, Tehran University of Medical Sciences, International Campus, Tehran, Iran | ||
| چکیده | ||
| Objective(s): Central γ-aminobutyric acid (GABA) neurotransmission modulates cardiovascular functions and sleep. Acute sleep deprivation (ASD) affects functions of various body organs via different mechanisms. Here, we evaluated the effect of ASD on cardiac ischemia/reperfusion injury (IRI), and studied the role of GABA-A receptor inhibition in central nucleus of amygdala (CeA) by assessing nitric oxide (NO) and oxidative stress. Materials and Methods: The CeA in sixty male Wistar rats was cannulated for saline or bicuculline (GABA-A receptor antagonist) administration. All animals underwent 30 min of coronary occlusion (ischemia), followed by 2 hr reperfusion (IR). The five experimental groups (n=12) included are as follows: IR: received saline; BIC+IR: received Bicuculline; MLP+IR: received saline, followed by the placement of animals in an aquarium with multiple large platforms; ASD+IR: underwent ASD in an aquarium with multiple small platforms; and BIC+ASD+IR: received bicuculline prior to ASD. Results: Bicuculline administration increased the malondialdehyde levels and infarct size, and decreased the NO metabolites levels and endothelial nitric oxide synthase (eNOS) gene expression in infarcted and non-infarcted areas in comparison to IR group. ASD reduced malondialdehyde levels and infarct size and increased NO metabolites, corticosterone levels and eNOS expression in infarcted and non-infarcted areas as compared to the IR group. Levels of malondialdehyde were increased while levels of NO metabolites, corticosterone and eNOS expression in infarcted and non-infarcted areas were reduced in the BIC+ASD+IR as compared to the ASD+IR group. Conclusion: Blockade of GABA-A receptors in the CeA abolishes ASD-induced cardioprotection by suppressing oxidative stress and NO production. | ||
| کلیدواژهها | ||
| Acute sleep deprivation؛ Bicuculline؛ GABA-A receptor؛ Infarct size؛ Myocardial ischemia/Reperfusion؛ Nitric oxide | ||
| مراجع | ||
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