First report of OXA-143-lactamase producing Acinetobacter baumannii inQom | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 15، دوره 20، شماره 11، بهمن 2017، صفحه 1282-1286 اصل مقاله (957.78 K) | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2017.9490 | ||
| نویسندگان | ||
| Zohreh Sarikhani1؛ Razieh Nazari* 1؛ Mahmoud Nateghi Rostami2 | ||
| 1Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran | ||
| 2Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Objective(s):Antibiotic resistance in Acinetobacter baumannii and outbreaks caused by this organism have been reported from several areas of the world. The present study aimed at determining the antibiotic susceptibility profiles and the distribution of OXA-type beta-lactamases among Iranian Acinetobacter baumannii isolates from Qom of Iran. Materials and Methods: For this study, 108 non-duplicate A. baumannii isolates were obtained from clinical specimens in four teaching hospitals in Qom in the central of Iran. The antimicrobial susceptibility of isolates was tested by standard disk diffusion and prevalence of bla OXA genes was investigated by PCR method. Results: Among 97 carbapenem non-susceptible isolates of A. baumannii, 90.72% (88 isolates) isolates showed extensive drug resistance to multiple antibiotics. Among carbapenem resistant isolates, 100% carried blaOXA-51-like, 82.47% carried blaOXA-23-like, 55.67% carried blaOXA-58-like, 22.68% carried blaOXA-40-like and 14.43% had blaOXA-143-like resistance genes. Conclusion: This study demonstrated high genetic diversity of OXA genes among isolates of A. baumannii in Qom, Iran. | ||
| کلیدواژهها | ||
| Acinetobacter baumannii؛ blaOXA-143؛ Carbapenem resistance؛ Iran؛ Polymerase chain reaction | ||
| مراجع | ||
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