The correlation of anandamide with gonadotrophin and sex steroid hormones during the menstrual cycle | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 13، دوره 20، شماره 11، بهمن 2017، صفحه 1268-1274 اصل مقاله (957.58 K) | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2017.9488 | ||
| نویسندگان | ||
| Na Cui؛ Luning Wang؛ Wei Wang؛ Jie Zhang؛ Yueming Xu؛ Lei Jiang؛ Guimin Hao* | ||
| Department of Reproduction, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China | ||
| چکیده | ||
| Objective(s): The purpose of this study was to investigate the change in plasma anandamide (AEA) levels throughout the normal menstrual cycle, and to analyze the relationship among AEA, sex steroids and gonadotrophins. Materials and Methods: The patients were fertile women with normal menstrual cycle, proposed to get in vitro fertilization (IVF) treatment due to oviduct obstruction or male infertility. Patients were divided into two groups, cross-sectional (n=79) and longitudinal (n=10). The plasma AEA levels were examined by the ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) system. The serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone (P) were measured by chemiluminescence. Results: The AEA levels in the late follicular phase were slightly higher than those in the early follicular phase. Subsequently, the AEA levels peaked at the time of ovulation in both two cohorts. Finally, the lowest AEA levels were measured in the luteal phase. Moreover, there were highly significant positive correlations between the plasma AEA concentration and the serum levels of FSH, LH and E2, whereas the AEA level was not correlated with P during the normal menstrual cycle. Conclusion: Our observations reveal a dynamic change in the plasma AEA level, which is closely associated with the levels of gonadotrophin and sex steroid hormones, suggesting that the hormones may be involved in the regulation of AEA levels during the menstrual cycle. Our studies help to design new strategies to improve implantation and treatments for reproductive diseases. | ||
| کلیدواژهها | ||
| Anandamide؛ Endocannabinoid؛ Gonadotrophin؛ Menstrual cycle؛ Sex steroid hormones | ||
| مراجع | ||
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1. Battista N, Bari M, and Maccarrone M. Endocannabinoids and Reproductive Events in Health and Disease. Handb Exp Pharmacol2015; 231: 341-365. 2. Meccariello R, Battista N, Bradshaw HB, and Wang H. Updates in reproduction coming from the endocannabinoid system. Int J Endocrinol2014; 2014: 412354. 3. Fride E. Endocannabinoids in the central nervous system--an overview. Prostaglandins Leukot Essent Fatty Acids2002; 66: 221-233. 4. Fride E and Shohami E. The endocannabinoid system: function in survival of the embryo, the newborn and the neuron. Neuroreport2002; 13: 1833-1841. 5. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science1992; 258: 1946-1949. 6. Sugiura T, Kondo S, Sukagawa A, Nakane S, Shinoda A, Itoh K, et al. 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun1995; 215: 89-97. 7. Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR, et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol1995; 50: 83-90. 8. De Petrocellis L, Cascio MG, and Di Marzo V. The endocannabinoid system: a general view and latest additions. Br J Pharmacol2004; 141: 765-774. 9. Porter AC, Sauer JM, Knierman MD, Becker GW, Berna MJ, Bao J, et al. Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor. J Pharmacol Exp Ther2002; 301: 1020-1024. 10. Bisogno T, Melck D, Bobrov M, Gretskaya NM, Bezuglov VV, De Petrocellis L, et al. N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. Biochem J2000; 351 Pt 3: 817-824. 11. Sugiura T, Kobayashi Y, Oka S, and Waku K. Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. Prostaglandins Leukot Essent Fatty Acids2002; 66: 173-192. 12. Okamoto Y, Morishita J, Tsuboi K, Tonai T, and Ueda N. Molecular characterization of a phospholipase D generating anandamide and its congeners. J Biol Chem2004; 279: 5298-5305. 13. Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, et al. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev2002; 54: 161-202. 14. Pertwee RG and Ross RA. Cannabinoid receptors and their ligands. Prostaglandins Leukot Essent Fatty Acids2002; 66: 101-121. 15. Pertwee RG, Ross RA, Craib SJ, and Thomas A. (-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens. Eur J Pharmacol2002; 456: 99-106. 16. McKinney MK and Cravatt BF. Structure and function of fatty acid amide hydrolase. Annu Rev Biochem2005; 74: 411-432. 17. Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, and Cravatt BF. A second fatty acid amide hydrolase with variable distribution among placental mammals. J Biol Chem2006; 281: 36569-36578. 18. Tsuboi K, Sun YX, Okamoto Y, Araki N, Tonai T, and Ueda N. Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. J Biol Chem2005; 280: 11082-11092. 19. Schuel H, Burkman LJ, Lippes J, Crickard K, Mahony MC, Giuffrida A, et al. Evidence that anandamide-signaling regulates human sperm functions required for fertilization. Mol Reprod Dev2002; 63: 376-387. 20. Gervasi MG, Rapanelli M, Ribeiro ML, Farina M, Billi S, Franchi AM, et al. The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction. Reproduction2009; 137: 403-414. 21. El-Talatini MR, Taylor AH, Elson JC, Brown L, Davidson AC, and Konje JC. Localisation and function of the endocannabinoid system in the human ovary. PLoS One2009; 4: e4579. 22. El-Talatini MR, Taylor AH, and Konje JC. Fluctuation in anandamide levels from ovulation to early pregnancy in in-vitro fertilization-embryo transfer women, and its hormonal regulation. Hum Reprod2009; 24: 1989-1998. 23. Karasu T, Marczylo TH, Maccarrone M, and Konje JC. The role of sex steroid hormones, cytokines and the endocannabinoid system in female fertility. Hum Reprod Update2011; 17: 347-361. 24. Maccarrone M, Valensise H, Bari M, Lazzarin N, Romanini C, and Finazzi-Agro A. Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility. J Immunol2001; 166: 7183-7189. 25. Maccarrone M, Bari M, Battista N, and Finazzi-Agro A. Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation. Blood2002; 100: 4040-4048. 26. Maccarrone M, Falciglia K, Di Rienzo M, and Finazzi-Agro A. Endocannabinoids, hormone-cytokine networks and human fertility. Prostaglandins Leukot Essent Fatty Acids2002; 66: 309-317. 27. Grisendi V, Spada E, Argento C, Plebani M, Milani S, Seracchioli R, et al. Age-specific reference values for serum FSH and estradiol levels throughout the reproductive period. Gynecol Endocrinol2014; 30: 451-455. 28. Ecochard R, Guillerm A, Leiva R, Bouchard T, Direito A, and Boehringer H. Characterization of follicle stimulating hormone profiles in normal ovulating women. Fertil Steril2014; 102: 237-243 e235. 29. Dimitraki M, Messini CI, Dafopoulos K, Gioka T, Koutlaki N, Garas A, et al. Attenuating activity of the ovary on LH response to GnRH during the follicular phase of the cycle. Clin Endocrinol (Oxf)2014; 80: 439-443. 30. Honnma H, Asada Y, Baba T, and Endo T. Continuous high-dose estrogen controls serum FSH and LH levels: new treatment strategy for extremely low ovarian reserve patients, two case reports. Gynecol Endocrinol2014; 30: 341-344. 31. Yang ZM, Paria BC, and Dey SK. Activation of brain-type cannabinoid receptors interferes with preimplantation mouse embryo development. Biol Reprod1996; 55: 756-761. 32. Schmid PC, Paria BC, Krebsbach RJ, Schmid HH, and Dey SK. Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation. Proc Natl Acad Sci U S A1997; 94: 4188-4192. 33. Wang J, Paria BC, Dey SK, and Armant DR. Stage-specific excitation of cannabinoid receptor exhibits differential effects on mouse embryonic development. Biol Reprod1999; 60: 839-844. 34. Paria BC, Das SK, and Dey SK. The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. Proc Natl Acad Sci U S A1995; 92: 9460-9464. 35. Habayeb OM, Taylor AH, Evans MD, Cooke MS, Taylor DJ, Bell SC, et al. Plasma levels of the endocannabinoid anandamide in women--a potential role in pregnancy maintenance and labor? J Clin Endocrinol Metab2004; 89: 5482-5487. 36. El-Talatini MR, Taylor AH, and Konje JC. The relationship between plasma levels of the endocannabinoid, anandamide, sex steroids, and gonadotrophins during the menstrual cycle. Fertil Steril2010; 93: 1989-1996. 37. Schlosburg JE, Kinsey SG, and Lichtman AH. Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation. AAPS J2009; 11: 39-44. 38. Gorzalka BB and Dang SS. Minireview: Endocannabinoids and gonadal hormones: bidirectional interactions in physiology and behavior. Endocrinology2012; 153: 1016-1024. | ||
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