Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 7، دوره 20، شماره 11، بهمن 2017، صفحه 1220-1226 اصل مقاله (1.34 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2017.9473 | ||
| نویسندگان | ||
| Qiang Yang؛ Wen-wen Wang؛ Pu Ma؛ Zhong-xuan Ma؛ Meng Hao؛ Temitope I Adelusi؛ Lei Du؛ Xiao-Xing Yin؛ Qian Lu* | ||
| Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, Jiangsu, China | ||
| چکیده | ||
| Objective(s): Increasing evidence suggests that regular physical exercise improves type 2 diabetes mellitus (T2DM). However, the potential beneficial effects of swimming on insulin resistance and lipid disorder in T2DM, and its underlying mechanisms remain unclear. Materials and Methods: Rats were fed with high fat diet and given a low dosage of Streptozotocin (STZ) to induce T2DM model, and subsequently treated with or without swimming exercise. An 8-week swimming program (30, 60 or 120 min per day, 5 days per week) decreased body weight, fasting blood glucose and fasting insulin. Results: Swimming ameliorated lipid disorder, improved muscular atrophy and revealed a reduced glycogen deposit in skeletal muscles of diabetic rats. Furthermore, swimming also inhibited the activation of Wnt3a/β-catenin signaling pathway, decreased Wnt3a mRNA and protein level, upregulated GSK3β phosphorylation activity and reduced the expression of β-catenin phosphorylation in diabetic rats. Conclusion: The trend of the result suggests that swimming exercise proved to be a potent ameliorator of insulin resistancein T2DM through the modulation of Wnt3a/β-catenin pathway and therefore, could present a promising therapeutic measure towards the treatment of diabetes and its relatives. | ||
| کلیدواژهها | ||
| GSK3β؛ insulin resistance؛ Swimming training؛ Type 2 diabetes mellitus؛ Wnt3a/β-catenin signaling | ||
| مراجع | ||
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