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Nasiry, Davood, Khalatbary, Ali Reza, Ahmadvand, Hassan. (1396). Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat. , 20(11), 1275-1281. doi: 10.22038/ijbms.2017.9465
Davood Nasiry; Ali Reza Khalatbary; Hassan Ahmadvand. "Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat". , 20, 11, 1396, 1275-1281. doi: 10.22038/ijbms.2017.9465
Nasiry, Davood, Khalatbary, Ali Reza, Ahmadvand, Hassan. (1396). 'Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat', , 20(11), pp. 1275-1281. doi: 10.22038/ijbms.2017.9465
Nasiry, Davood, Khalatbary, Ali Reza, Ahmadvand, Hassan. Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat. , 1396; 20(11): 1275-1281. doi: 10.22038/ijbms.2017.9465

Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat

Iranian Journal of Basic Medical Sciences
مقاله 14، دوره 20، شماره 11، بهمن 2017، صفحه 1275-1281    اصل مقاله (1.19 M)
شناسه دیجیتال (DOI): 10.22038/ijbms.2017.9465
نویسندگان
Davood Nasiry1؛ Ali Reza Khalatbary* 2؛ Hassan Ahmadvand3، 4
1Anatomy Department, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
2Molecular and Cell Biology Research Center, Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
4Razi Herbal Researches Center, Lorestan University of Medical Sciences, Khorramabad, Iran
چکیده
Objective(s): Oxidative stress has a pivotal role in the pathogenesis of diabetic retinopathy (DR). Juglans regia L. (JRL) leaf extract has hypoglycemic and antioxidative properties. This study aimed to determine the ameliorative effects of JRL against diabetic retinopathy.
Materials and Methods: The DR rat model was generated by injection of streptozotocin (STZ). A subset of the diabetic rats received JRL or metformin after the onset of hyperglycemia. Histopathology and immunohistochemistry of apoptotic and inflammatory factors were assessed along with biochemical assessments of lipid peroxidation and antioxidant status.
Results: Lipid peroxidation level and catalase activity significantly improved after JRL consumption (PPP Conclusion: JRL leaf extract exert protective effects against diabetic retinopathy.
کلیدواژه‌ها
Antioxidant؛ Apoptosis؛ Diabetic retinopathy؛ Hyperglycemia؛ Inflammation؛ Juglans regia L. leaf
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