Effect of Apium graveolens and Trachyspermum copticom on clinical symptoms of patients with functional dyspepsia | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 201، دوره 7، شماره 6، بهمن و اسفند 2017، صفحه 554-564 اصل مقاله (568.21 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2017.20630.1786 | ||
| نویسندگان | ||
| Maryam Azimi1؛ Mohammad Javad Zahedi* 2؛ Mitra Mehrabani3؛ Haleh Tajadini1؛ Farzaneh Zolala4؛ Mohammad Baneshi5؛ Rasool Choopani6؛ Fariba Sharififar7؛ Ali Asadipour7؛ Mohammad Hayatbakhsh2؛ Bijan Ahmadi2 | ||
| 1Department of Traditional Medicine, School of Traditional Medicine, Kerman University of Medical Sciences, Kerman, Iran | ||
| 2Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran | ||
| 3Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran | ||
| 4Associate Professor of Biostatistics Modeling in Health Research Center Institute for Futures Studies in Health Kerman University of Medical Sciences, Kerman, Iran | ||
| 5Biostatistics and Epidemiology Department, Modeling in Health Research Center, Institute for Futures Studies in Health Kerman University of Medical Sciences, Kerman, Iran | ||
| 6Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran | ||
| 7Herbal and Traditional Medicines Center, Kerman University of Medical Science, Kerman, Iran | ||
| چکیده | ||
| Objectives:This study aimed at investigating the effect of Iranian traditional remedy prepared from Apium graveolens and Trachyspermum copticom (AT) on the severity and frequency of symptoms in patients with functional dyspepsia (FD). Material and Methods:In total, 150 FD patients were included in this randomized double-blind trial, based on the ROME III diagnostic criteria, and they were divided into three intervention groups namely, AT, Placebo and omeprazole. Then, severity and frequency of symptoms during this eight-week trial were measured. Obtained information was analyzed using Chi-square test and repeated measures test. Result:In general, the severity and frequency of symptoms after the 4th week significantly decreased in the AT group as compared to the omeprazole and placebo groups, and continued to reduce by the end of the eighth week. General reduction of symptom severity and frequency in the omeprazole group was significantly different from the placebo group by the end of the 4th and 8th weeks. With respect to each individual symptom, AT markedly improved symptoms, such as burning, pain, early satiation, fullness, bloating, belching and nausea, as compared to placebo-treated group. Moreover, AT significantly improved symptoms, like vomiting, and nausea, except for pain, as compared to omeprazole-treated subjects. Conclusion:According to the results, AT, as Iranian traditional remedy, was more effective than omeprazole and placebo in reducing the symptoms in FD patients. | ||
| کلیدواژهها | ||
| IranianTraditional medicine؛ Apium Graveolens؛ Trachyspermum Copticom؛ Functional Dyspepsia | ||
| مراجع | ||
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