Role of basal stress hormones and amygdala dimensions in stress coping strategies of male rhesus monkeys in response to a hazard-reward conflict | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 15، دوره 20، شماره 8، آبان 2017، صفحه 951-957 اصل مقاله (1.03 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2017.9120 | ||
| نویسندگان | ||
| Elaheh Tekieh1؛ Esmail Riahi2؛ Masoomeh Kazemi1؛ Hedayat Sahraei1؛ Hassan Tavakoli1؛ Hamed Aliyary3؛ Mostafa Hajinasrollah4؛ Maryam Salehi1؛ Gholamhossein Meftahi1؛ Mehdi Saberi* 5 | ||
| 1Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran | ||
| 2Department of Physiology, Tehran University of Medical Sciences, Tehran, Iran | ||
| 3Department of Electrical, Biomedical and Mechatronics Engineering, Qazvin Branch, Islamic Azad University, Qazvin, Iran | ||
| 4Animal Core Facility, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Tehran, Iran | ||
| 5Department of Pharmacology & Toxicology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Objective(s): In the present study the effect of stress on monkeys that had learned to retrieve food from a five-chamber receptacle, as well as the relationship between their behavior and the serum cortisol and epinephrine levels and relative size of the amygdala was evaluated. Materials and Methods: Six male rhesus monkeys were individually given access to the food reward orderly. They could easily retrieve the rewards from all chambers except for the chamber 4, which a brief, mild electric shock (3 V) was delivered to them upon touching the chamber’s interior. The coping behaviors were video-recorded and analyzed offline. Baseline serum cortisol and epinephrine levels were measured before the experiments using monkey enzyme-linked immunosorbent assay kit. One week after the behavioral experiment, the monkeys’ brains were scanned using magnetic resonance imaging under general anesthesia. The cross-sectional area of the left amygdala in sagittal plane relative to the area of the whole brain in the same slice was evaluated by the planimetric method using ImageJ software. Results: Exposure to the distressing condition caused different behavioral responses. Monkeys with higher baseline levels of serum cortisol and epinephrine and larger amygdala behaved more violently in the face of stress, indicating adopting emotion-focused stress-coping strategies. Conversely, those with low plasma epinephrine, moderate cortisol, and smaller amygdala showed perseverative behavior, indicating a problem-focused coping style. Conclusion: In dealing with the same stress, different responses might be observed from nonhuman primates according to their cortisol and epinephrine levels as well as their amygdala dimensions. | ||
| کلیدواژهها | ||
| Amygdala؛ Coping strategies؛ Cortisol؛ epinephrine؛ Rhesus macaque؛ stress | ||
| مراجع | ||
|
1. Driskell JE, Salas E. Stress and human performance: Psychology Press; 2013.
2. Elliott GR, Eisdorfer C. Stress and human health: analysis and implications of research: a study: Springer Publishing Company; 1982.
3.Wingfield JC. Control of behavioural strategies for capricious environments. Anim Behav 2003; 66:807-816.
4. Pfattheicher S, Keller J. Towards a biopsychological understanding of costly punishment: the role of basal cortisol. PLoS One 2014; 9:e85691.
5. de Boer SF, Koolhaas JM. 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis. Eur J Pharmacol 2005; 526:125-139.
6. Carver CS, Scheier MF, Weintraub JK. Assessing coping strategies: a theoretically based approach. J Pers Soc Psychol 1989; 56:267.
7. Billings AG, Moos RH. The role of coping responses and social resources in attenuating the stress of life events. J Behav Med 1981; 4:139-157.
8. Dumont M, Provost MA. Resilience in adolescents: Protective role of social support, coping strategies, self-esteem, and social activities on experience of stress and depression. J Youth Adolesc 1999; 28:343-363.
9. Felton BJ, Revenson TA. Coping with chronic illness: a study of illness controllability and the influence of coping strategies on psychological adjustment. J Consult Clin Psychol 1984; 52:343.
10. Montoya ER, Terburg D, Bos PA, van Honk J. Testosterone, cortisol, and serotonin as key regulators of social aggression: A review and theoretical perspective. Motiv Emot 2012; 36:65-73.
11. Singh-Taylor A, Korosi A, Molet J, Gunn BG, Baram TZ. Neurobiology of Stress 2014.
12. Wadhwa PD, Sandman CA, Garite TJ. The neurobiology of stress in human pregnancy: implications for prematurity and development of the fetal central nervous system. Prog Brain Res 2001; 133:131-142.
13. Smith SM, Vale WW. The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci 2006; 8:383-395.
14. Christensen NJ. The biochemical assessment of sympathoadrenal activity in man. Clin Auton Res 1991; 1:167-172.
15. Kudielka BM, Buske-Kirschbaum A, Hellhammer DH, Kirschbaum C. HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults, and children: impact of age and gender. Psychoneuroendocrinology 2004; 29:83-98.
16. Kudielka BM, Schommer NC, Hellhammer DH, Kirschbaum C. Acute HPA axis responses, heart rate, and mood changes to psychosocial stress (TSST) in humans at different times of day. Psychoneuroendocrinology 2004; 29:983-992.
17. Buske-Kirschbaum A, Fischbach S, Rauh W, Hanker J, Hellhammer D. Increased responsiveness of the hypothalamus–
pituitary–adrenal (HPA) axis to stress in newborns with atopic disposition. Psychoneuroendocrinology 2004; 29:705-711.
18. Mihai CT, Rotinberg P, Brinza F, Vochita G. Extremely low-frequency electromagnetic fields cause DNA strand breaks in normal cells. J Environ Health Sci Eng 2014; 12:15.
19. Wong DL. Epinephrine biosynthesis: hormonal and neural control during stress. Cell Mol Neurobiol 2006; 26:891-900.
20. Amaral DG. The primate amygdala and the neurobiology of social behavior: implications for understanding social anxiety. Biol Psychiatry 2002; 51:11-17.
21. Phelps EA, LeDoux JE. Contributions of the amygdala to emotion processing: from animal models to human behavior. Neuron 2005; 48:175-187.
22. Shanthi V, Singh D. Estimation of hippocampus volume from MRI using imageJ for alzheimer’s diagnosis. Atlas J Med Biol Sci 2011; 1:15 –20.
23. Scotti MA, Rendon NM, Greives TJ, Romeo RD, Demas GE. Short-day aggression is independent of changes in cortisol or glucocorticoid receptors in male Siberian hamsters (Phodopus sungorus). J Exp Zool A Ecol Genet Physiol 2015; 323:331-341.
24. Thoits PA. Stress, coping, and social support processes: Where are we? What next? J Health Soc Behav 1995; Spec No:53-79.
25. de Quervain DJ, Roozendaal B, Mc Gaugh JL. Stress and glucocorticoids impair retrieval of long-term spatial memory. Nature 1998; 394:787-790.
26. Clow A, Hucklebridge F, Stalder T, Evans P, Thorn L. The cortisol awakening response: more than a measure of HPA axis function. Neurosci Biobehav Rev 2010; 35:97-103.
27. Clutton-Brock TH, Parker GA. Punishment in animal societies. Nature 1995; 373:209-216.
28. Yahyavi ST, Zarghami M, Naghshvar F, Danesh A. Relationship of cortisol, norepinephrine, and epinephrine levels with war-induced posttraumatic stress disorder in fathers and their offspring. Rev Bras Psiquiatr 2015; 37:93-98.
29. Kruk MR, Halasz J, Meelis W, Haller J. Fast positive feedback between the adrenocortical stress response and a brain mechanism involved in aggressive behavior. Behav Neurosci 2004; 118:1062.
30. Saltzman W, Abbott DH. Effects of elevated circulating cortisol concentrations on maternal behavior in common marmoset monkeys (Callithrix jacchus). Psychoneuroendo- crinology 2009; 34:1222-1234.
31. Bohnke R, Bertsch K, Kruk MR, Naumann E. The relationship between basal and acute HPA axis activity and aggressive behavior in adults. J Neural Transm (Vienna) 2010; 117:629-637. 32. Carpenter RE, Korzan WJ, Bockholt C, Watt MJ, Forster GL, Renner KJ, et al. Corticotropin releasing factor influences aggression and monoamines: modulation of attacks and retreats. Neuroscience 2009; 158:412-425.
33. Lupien SJ, McEwen BS. The acute effects of corticosteroids on cognition: integration of animal and human model studies. Brain Res Rev 1997; 24:1-27.
34. Andolina D, Maran D, Valzania A, Conversi D, Puglisi-Allegra S. Prefrontal/amygdalar system determines stress coping behavior through 5-HT/GABA connection. Neuro-psychopharmacology 2013; 38:2057-2067.
35. Vafaei A, Rashidy-Pour A, Taherian A. Peripheral injection of corticosterone has different effects on consolidation and retrieval spatial memory. Tabriz Pharmaciutical Sci 2009; 14:237-245. | ||
|
آمار تعداد مشاهده مقاله: 1,280 تعداد دریافت فایل اصل مقاله: 995 |
||