Protective effects of erythropoietin against cuprizone-induced oxidative stress and demyelination in the mouse corpus callosum | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 7، دوره 20، شماره 8، آبان 2017، صفحه 886-893 اصل مقاله (1.42 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2017.9110 | ||
| نویسندگان | ||
| Iraj Ragerdi Kashani* 1؛ Hossein Chavoshi1؛ Parichehr Pasbakhsh1؛ Mahmoud Hassani2؛ Ameneh Omidi3؛ Reza Mahmoudi4؛ Cordian Beyer5؛ Adib Zendedel5 | ||
| 1Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| 2Department of Medical Nanotechnologies, School of Advanced Technologies, Tehran University of Medical Sciences, Tehran, Iran | ||
| 3Department of Anatomical Sciences, Medical Sciences Faculty, Tarbiat Modares University, Tehran, Iran | ||
| 4Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran | ||
| 5Faculty of Medicine, Institute of Neuroanatomy, RWth Aachen University, Aachen, Germany | ||
| چکیده | ||
| Objective(s): Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis. The aim of the present work is to investigate the protective effects of erythropoietin against cuprizone-induced oxidative stress. Materials and Methods: Adult male C57BL/6J mice were fed a chow containing 0.2 % cuprizone for 6 weeks. After 3 weeks, mice were simultaneously treated with erythropoietin (5,000 IU/ kg body weight) by daily intraperitoneal injections. Results: Our results showed that cuprizone induced oxidative stress accompanied with down-regulation of subunits of the respiratory chain complex and demyelination of corpus callosum. Erythropoietin antagonized these effects. Biochemical analysis showed that oxidative stress induced by cuprizone was regulated by erythropoietin. Similarly, erythropoietin induced the expression of subunits of the respiratory chain complex over normal control values reflecting a mechanism to compensate cuprizone-mediated down-regulation of these genes. Conclusion: The data implicate that erythropoietin abolishes destructive cuprizone effects in the corpus callosum by decreasing oxidative stress and restoring mitochondrial respiratory enzyme activity. | ||
| کلیدواژهها | ||
| Cuprizone؛ Demyelination؛ Erythropoietin؛ Multiple Sclerosis؛ Oxidative stress | ||
| مراجع | ||
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