Unexplained High Activity of Aspartate Aminotransferase in an Asymptomatic Pediatric Patient | ||
| Journal of Pediatric Perspectives | ||
| مقاله 1، دوره 5، شماره 10 - شماره پیاپی 46، دی 2017، صفحه 5805-5808 اصل مقاله (145.7 K) | ||
| شناسه دیجیتال (DOI): 10.22038/ijp.2017.25420.2162 | ||
| نویسندگان | ||
| Wajiha Maan1؛ Qurratul Ann Warsi2؛ Avideh Rashed1؛ Manoochehr Karjoo* 3 | ||
| 1Department of Pediatrics, Golisano Children's Hospital, Upstate Medical University, Syracuse, NY, USA. | ||
| 2University of California and San Francisco, Department of Epidemiology and Biostatistics, San Francisco, CA, USA. | ||
| 3Pediatric Gastroenterology, Hepatology and Nutrition, Golisano Children's Hospital, Upstate Medical University, Syracuse, NY, USA. | ||
| چکیده | ||
| Elevated enzyme activities in plasma may at times be attributed to the presence of macro-enzymes. The macro-enzymes are often serum enzymes in complex with immunoglobulins, resulting in a greater molecular mass that cannot be filtered by renal glomeruli and are, hence, retained in the plasma. The aspartate aminotransferase (AST) can exist as a macro-enzyme, although it has been rarely reported. We describe a pediatric patient with persistently elevated serum AST activity, due to macro-enzyme formation between AST and an immunoglobulin. This is to highlight the importance of early diagnosis of macro-AST in an otherwise asymptomatic pediatric patient with isolated AST-elevation and to avoid unnecessary costly testing. | ||
| کلیدواژهها | ||
| Alanine؛ Alkaline phosphatase؛ Aspartate Aminotransferase؛ Child؛ macro-enzymes | ||
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