The effect of Zataria multiflora and carvacrol on wheezing, FEV1 and plasma levels of nitrite in asthmatic patients | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 199، دوره 7، شماره 6، بهمن و اسفند 2017، صفحه 531-541 اصل مقاله (696.3 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2017.24102.1883 | ||
| نویسندگان | ||
| Azam Alavinezhad؛ Mahdiyeh Hedayati؛ Mohammad Hossein Boskabady* | ||
| Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective: The preventive effect of Zataria multiflora in animal models of asthma has been reported. In the present study, its effect on wheezing, forced expiratory volume in 1 second, and plasma nitrite (NO2-) in asthmatic patients was studied. Materials and Methods: In this study, forty asthmatic patients including 15 males and 25 females (aged 45.8±6.21 years) were randomly allocated in four groups including placebo group (P), and three treatment groups which received two doses of Z. multiflora (groups Z low and Z high that received 5 and 10 mg/kg/day, respectively) and carvacrol (group C treated with 1.2 mg/kg/day). All patients were treated for two months in a double-blind manner. At three time points (before starting the treatment (pretreatment), and one and two month after treatment), wheezing during day and exercise, forced expiratory volume in 1 second and NO2- were measured. Results: Day wheeze and exercise wheeze were significantly reduced in treated groups with carvacrol and both doses of Z. multiflora compared to pretreatment (p1% was significantly increased in treated groups with carvacrol and both doses of Z. multiflora (p2- was also significantly decreased in Z high and carvacrol groups after two months of treatment (p Conclusion: Z. multiflora and its constituent, carvacrol, improved FEV1% while reduced wheezing and plasma level of NO2- in asthmatic patients. Therefore, a possible therapeutic potential for this plant and its constituent, carvacrol could be suggested to be used against asthma. | ||
| کلیدواژهها | ||
| Asthma؛ Zataria multiflora؛ Carvacrol؛ Forced expiratory volume in one second؛ Wheezing؛ Nitrite | ||
| مراجع | ||
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