Association of Helicobacter Pylori Infection with Cardiometabolic Risk Factors among Iranian Adolescents: the CASPIAN III Study | ||
| Journal of Pediatric Perspectives | ||
| مقاله 5، دوره 6، شماره 2 - شماره پیاپی 50، اردیبهشت 2018، صفحه 7045-7054 اصل مقاله (469.23 K) | ||
| نوع مقاله: original article | ||
| شناسه دیجیتال (DOI): 10.22038/ijp.2017.24411.2060 | ||
| نویسندگان | ||
| Enayat Kalantar1؛ Mohammand Javad Gharavi2؛ Shervin Ghaffari Hoseini3؛ Ramin Heshmat4؛ Mojgan Oshaghi1؛ Behnaz Gharegozlou1؛ Hamid Asayesh5؛ Armita Mahdavi Gorabi4؛ Mohammad Esmaeil Motlagh6؛ Mehdi Noroozi7؛ Mostafa Qorbani* 8؛ Roya Kelishadi* 9 | ||
| 1Dietary Supplements and Probiotics Research Center, Alborz University of Medical Sciences, Karaj, Iran. | ||
| 2Department of Microbiology and Immunology, School of Paramedical Sciences, Iran University of Medical Sciences, Tehran, Iran. | ||
| 3Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. | ||
| 4Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. | ||
| 5Department of Medical Emergencies, Qom University of Medical Sciences, Qom, Iran. | ||
| 6Department of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. | ||
| 7Social Determinants of Health Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. | ||
| 8Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran & Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. | ||
| 9Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. | ||
| چکیده | ||
| Background: At least half the world’s population is colonized the stomach by Helicobacter pylori (H. pylori) which are a key constituent of the human microbiome. The aim of this study was to investigate the association of cardiometabolic risk factors with H. pylori infection in Iranian adolescents. Materials and Methods: The current study was conducted along with the third survey of a national school-based surveillance system in Iran, entitled "Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Disease" (CASPIAN) study. Detailed questionnaires on demographic, socioeconomic, dietary, and health-related information of the participants were filled by one of the parents under supervision of trained health-care workers. Trained healthcare professionals measured anthropometric indices, blood pressures according to standard protocols. Fasting venous blood was examined for fasting blood sugar and lipid profile. Results: Overall 882 serum samples were suitable for testing. H. pylori antibody was found in 643 serum samples (72.9%). Among cardiometabolic risk factors, only the mean weight of participants was different between two groups (44.6±11.8 in H. pylori positive and 42.8±11.3 in H. pylori negative group; p=0.04). Overall, 5.1% of adolescents with positive H. pylori tests were overweight or obese, while 1.7% of negative ones were so (p=0.02). In the multivariate regression model, H. pyloriseropositivity increased the risk of overweight (OR, 3.3; 95%CI, 1.2-9.3; p= 0.03). In the multivariate model, association of other cardiometabolic risk factors with H. pylori infection was not statistically significant (p>0.05). Conclusion: Results of present study showed that H. pylori infection was associated with excess weight in adolescents. H. pylori eradication may be decrease the risk of obesity. | ||
| کلیدواژهها | ||
| Adolescent؛ Helicobacter pylori؛ Iran؛ metabolic syndrome | ||
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