Protective effect of royal jelly on the sperm parameters and testosterone level and lipid peroxidation in adult mice treated with oxymetholone | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 5، دوره 4، شماره 1، فروردین و اردیبهشت 2014، صفحه 43-52 اصل مقاله (327.35 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2014.896 | ||
| نویسندگان | ||
| Ensieh Zahmatkesh1؛ Gholamreza Najafi* 2؛ Vahid Nejati1؛ Reza Heidari3 | ||
| 1Department of Histology and Embryology, Faculty of Science, Urmia University, Urmia, I. R. Iran | ||
| 2Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, I. R. Iran | ||
| 3Department of Biochemistry, Faculty of Science, Urmia University, Urmia, I. R. Iran | ||
| چکیده | ||
| Objectives: The aim of the present study was to evaluate protective effect of royal jelly on sperm parameters, testosterone level, and malondialdehyde (MDA) production in mice. Materials and Methods: Thirty-two adult male NMRI mice weighing 30±2 g were used. All the animals were divided into 4 groups. Control group: received saline 0.1 ml/mouse/day orally for 30 days. Royal Jelly group (RJ): received royal jelly at dose of 100 mg/kg daily for 30 days orally. Oxymetholone group: the received Oxymetholone (OX) at dose of 5 mg/kg daily for 30 days orally. Royal Jelly+Oxymetholone group: received royal jelly at dose of 100 mg/kg/day orally concomitant with OX administration. Sperm count, sperm motility, viability, maturity, and DNA integrity were analyzed. Furthermore, serum testosterone and MDA concentrations were determined. Results: In Oxymetholone group, sperm count, motility as well as testosterone concentration reduced significantly (p<0.05), while significant (p<0.05) increases in immature sperm, sperm with DNA damaged, and MDA concentration were announced in Oxymetholone group in comparison with control group and Royal Jelly+Oxymetholone group. RJ caused partially amelioration in all of the above- mentioned parameters in Royal Jelly+Oxymetholone group. Conclusion: In conclusion, RJ may be used in combination with OX to improve OX-induced oxidative stress and male infertility. | ||
| کلیدواژهها | ||
| Mice؛ Oxymetholone؛ Royal jelly؛ Sperm | ||
| مراجع | ||
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