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Sasannezhad, Payam, Ghabeli Juibari, Ali, Sadri, Kayvan, Dabbagh Kakhki, Vahidreza, Sadeghi, Ramin, Sabour, Mahsa, Alizadeh, Hesam. (1396). 99mTc-TRODAT-1 SPECT Imaging in Early and Late Onset Parkinson’s Disease. , 5(2), 119-125. doi: 10.22038/aojnmb.2017.8844
Payam Sasannezhad; Ali Ghabeli Juibari; Kayvan Sadri; Vahidreza Dabbagh Kakhki; Ramin Sadeghi; Mahsa Sabour; Hesam Alizadeh. "99mTc-TRODAT-1 SPECT Imaging in Early and Late Onset Parkinson’s Disease". , 5, 2, 1396, 119-125. doi: 10.22038/aojnmb.2017.8844
Sasannezhad, Payam, Ghabeli Juibari, Ali, Sadri, Kayvan, Dabbagh Kakhki, Vahidreza, Sadeghi, Ramin, Sabour, Mahsa, Alizadeh, Hesam. (1396). '99mTc-TRODAT-1 SPECT Imaging in Early and Late Onset Parkinson’s Disease', , 5(2), pp. 119-125. doi: 10.22038/aojnmb.2017.8844
Sasannezhad, Payam, Ghabeli Juibari, Ali, Sadri, Kayvan, Dabbagh Kakhki, Vahidreza, Sadeghi, Ramin, Sabour, Mahsa, Alizadeh, Hesam. 99mTc-TRODAT-1 SPECT Imaging in Early and Late Onset Parkinson’s Disease. , 1396; 5(2): 119-125. doi: 10.22038/aojnmb.2017.8844

99mTc-TRODAT-1 SPECT Imaging in Early and Late Onset Parkinson’s Disease

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 6، دوره 5، شماره 2، مهر 2017، صفحه 119-125    اصل مقاله (718.44 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/aojnmb.2017.8844
نویسندگان
Payam Sasannezhad1؛ Ali Ghabeli Juibari1؛ Kayvan Sadri2؛ Vahidreza Dabbagh Kakhki* 2؛ Ramin Sadeghi2؛ Mahsa Sabour2؛ Hesam Alizadeh2
1Department of Neurology, Mashhad University of Medical Sciences, Mashhad, Iran
2Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s): 99mTc-TRODAT-1, which binds to the dopamine transporter, could be used to image the dopaminergic system in diagnosis of Parkinson’s disease (PD). PD can be classified into two groups: late onset Parkinson’s disease (LOPD) and early onset Parkinson’s disease (EOPD). In this study we tried to determine the TRODAT SPECT findings in EOPD as compared to LOPD.
Methods: Fifteen patients were studied. The diagnosis of PD was defined by clinical criteria based on UK Parkinson’s Disease Society Brain Bank criteria. Six patients whose age at onset of PD were younger than 50 were defined as patients with EOPD and 9 patients with older than 50 years were defined as patients with LOPD. All patients underwent 99mTc-TRODAT Brain SPECT.
Results: There was a significant decrease of striatal 99mTc-TRODAT-1 (TRODAT) binding in PD patients in both EOPD and LOPD. No significant difference was noticed between EOPD and LOPD in disease stage and symptoms. In visual analysis, 20 (66.67%) caudate nucleuses had decreased tracer uptake while all 30 (100%) putamens had decreased or absent tracer uptake. No significant difference between EOPD and LOPD was noticed in visual analysis. Striatum, Caudate and Putamen uptake ratio to background were calculated. No significant difference was noticed between EOPD and LOPD in these ratios. However there was significant difference in visual analysis (tracer uptake) as well as in uptake ratio between putamen and caudate nucleuses in both groups (P=0.001). On the other word, we found more diminished uptake in putamen as compared the caudate. Frequency and severity of putamen involvement were much more than caudate.
Conclusion: 99mTc-TRODAT-1 SPECT imaging showed lower presynaptical dopami-nergical terminals density in both EOPD and LOPD. There was no difference between EOPD and LOPD in TRODAT uptake. Putamen showed more involvement and more diminished TRODAT uptake.

 
کلیدواژه‌ها
Tc-99m-TRODAT-1؛ Parkinson's disease؛ Early onset؛ Late onset؛ dopamine transporter
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