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Tsuyuguchi, Naohiro, Terakawa, Yuzo, Uda, Takehiro, Nakajo, Kosuke, Kanemura, Yonehiro. (1396). Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging With 18F- Fluciclovine: A Comparison Study With L-Methyl-11C-Methionine PET Imaging. , 5(2), 86-96. doi: 10.22038/aojnmb.2017.8843
Naohiro Tsuyuguchi; Yuzo Terakawa; Takehiro Uda; Kosuke Nakajo; Yonehiro Kanemura. "Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging With 18F- Fluciclovine: A Comparison Study With L-Methyl-11C-Methionine PET Imaging". , 5, 2, 1396, 86-96. doi: 10.22038/aojnmb.2017.8843
Tsuyuguchi, Naohiro, Terakawa, Yuzo, Uda, Takehiro, Nakajo, Kosuke, Kanemura, Yonehiro. (1396). 'Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging With 18F- Fluciclovine: A Comparison Study With L-Methyl-11C-Methionine PET Imaging', , 5(2), pp. 86-96. doi: 10.22038/aojnmb.2017.8843
Tsuyuguchi, Naohiro, Terakawa, Yuzo, Uda, Takehiro, Nakajo, Kosuke, Kanemura, Yonehiro. Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging With 18F- Fluciclovine: A Comparison Study With L-Methyl-11C-Methionine PET Imaging. , 1396; 5(2): 86-96. doi: 10.22038/aojnmb.2017.8843

Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging With 18F- Fluciclovine: A Comparison Study With L-Methyl-11C-Methionine PET Imaging

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 2، دوره 5، شماره 2، مهر 2017، صفحه 86-96    اصل مقاله (2.22 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/aojnmb.2017.8843
نویسندگان
Naohiro Tsuyuguchi* 1؛ Yuzo Terakawa2؛ Takehiro Uda1؛ Kosuke Nakajo1؛ Yonehiro Kanemura3
1Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan
2Department of Neurosurgery, Hokkaido Oono Memorial Hospital, Osaka, Japan
3Department of neurosurgery, Kansai Molecular Diagnosis Network for CNS Tumors, Osaka National Hospital, Osaka, Japan
چکیده
Objective(s): 18F-fluciclovine (trans-1-amino-3-[18F] fluorocyclobutanecarboxylic acid, [FACBC]) is an artificial amino acid radiotracer used for positron emission tomography (PET) studies, which is metabolically stable in vivo and has a long half-life. It has already been shown that FACBC-PET is useful for glioma imaging. However, there have been no reports evaluating the efficiency of FACBC-PET in the diagnosis of brain tumors in comparison with other PET tracers in clinical studies. The purpose of this study was to investigate the efficacy of FACBC-PET imaging in glioma diagnosis, compared to l-methyl-11C-methionine (MET)-PET.
Methods: Six consecutive patients (four male, two female), who were clinically suspected of having high- or low-grade glioma, received both FACBC-PET and MET-PET within a two-week interval. T1-weighted, contrast-enhanced, T1-weighted, and fluid-attenuated inversion recovery magnetic resonance imaging was performed to assist with subsequent tissue resection. Visual findings and semi-quantitative analyses of FACBC and MET uptake, using standardized uptake values (SUVs) and lesion-to-contralateral normal brain tissue (LN) ratios, were evaluated to compare PET images.
Results: SUVs for FACBC were lower than those for MET in the non-lesion cerebral cortex, brain stem, and cerebellar hemisphere. There was a weak positive correlation between FACBC and MET uptake in glioma tissue, although L/N ratios for FACBC were higher than those for MET in all the cases.
Conclusion: FACBC-PET showed higher contrast than MET-PET by both visual and semi-quantitative analyses and may therefore provide better assessment for the detection of glioma. This study was registered as clinical trial (No. JapicCTI-132289).

 
کلیدواژه‌ها
11C-Methionine؛ 18F-fluciclovine؛ Glioma؛ Positron Emission Tomography
مراجع
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