Ma, Lili, Ni, Hailai, Zou, Xinrong, Yuan, Yanyan, Luo, Chun, Liu, Bingyang, Wang, Fuyan, Xi, Yang, Chu, Yudong, Xu, Pangjie, Qiu, Xiaohui, Li, Song, Bu, Shizhong. (1396). Mori cortex prevents kidney damage through inhibiting expression of inflammatory factors in the glomerulus in streptozocin-induced diabetic rats. , 20(6), 715-721. doi: 10.22038/ijbms.2017.8842
Lili Ma; Hailai Ni; Xinrong Zou; Yanyan Yuan; Chun Luo; Bingyang Liu; Fuyan Wang; Yang Xi; Yudong Chu; Pangjie Xu; Xiaohui Qiu; Song Li; Shizhong Bu. "Mori cortex prevents kidney damage through inhibiting expression of inflammatory factors in the glomerulus in streptozocin-induced diabetic rats". , 20, 6, 1396, 715-721. doi: 10.22038/ijbms.2017.8842
Ma, Lili, Ni, Hailai, Zou, Xinrong, Yuan, Yanyan, Luo, Chun, Liu, Bingyang, Wang, Fuyan, Xi, Yang, Chu, Yudong, Xu, Pangjie, Qiu, Xiaohui, Li, Song, Bu, Shizhong. (1396). 'Mori cortex prevents kidney damage through inhibiting expression of inflammatory factors in the glomerulus in streptozocin-induced diabetic rats', , 20(6), pp. 715-721. doi: 10.22038/ijbms.2017.8842
Ma, Lili, Ni, Hailai, Zou, Xinrong, Yuan, Yanyan, Luo, Chun, Liu, Bingyang, Wang, Fuyan, Xi, Yang, Chu, Yudong, Xu, Pangjie, Qiu, Xiaohui, Li, Song, Bu, Shizhong. Mori cortex prevents kidney damage through inhibiting expression of inflammatory factors in the glomerulus in streptozocin-induced diabetic rats. , 1396; 20(6): 715-721. doi: 10.22038/ijbms.2017.8842

Mori cortex prevents kidney damage through inhibiting expression of inflammatory factors in the glomerulus in streptozocin-induced diabetic rats

Iranian Journal of Basic Medical Sciences
مقاله 14، دوره 20، شماره 6، 2017، صفحه 715-721    اصل مقاله (1.3 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2017.8842
نویسندگان
Lili Ma1؛ Hailai Ni2؛ Xinrong Zou1؛ Yanyan Yuan1؛ Chun Luo1؛ Bingyang Liu1؛ Fuyan Wang1؛ Yang Xi1؛ Yudong Chu3؛ Pangjie Xu3؛ Xiaohui Qiu3؛ Song Li4؛ Shizhong Bu* 1
1Runliang Diabetes Laboratory, Diabetes Research Center, Ningbo University. Ningbo, Zhejiang, PR China
2Department of Prevention and Health, Changhai Hospital, Second Military Medical University, Shanghai, PR China
3Department of Nephrology, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo, Zhejiang, PR China
4Center for Pharmacogenetics, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA
چکیده
Objective(s): It has been widely reported that Mori cortex extract (MCE) is used for the treatment of diabetes mellitus in traditional medicine. The present study was designed to investigate its mechanism of action in the treatment of diabetic nephropathy (DN). We assessed whether MCE preventive treatment ameliorates kidney damage in high-fat diet and streptozotocin (STZ)-induced type 2 diabetic rats.
Materials and Methods: Rats were fed a high-fat diet and injected with STZ. MCE was given to rats daily at 10 g/kg. Fasting blood glucose (FBG) and postprandial plasma glucose were measured. Blood and urine biochemical parameters, renal tissue morphology, and inflammation were investigated.
Results: Prevention with MCE significantly decreased FBG and homoeostasis model assessment (HOMA) of IR (HOMA-IR) levels and increased insulin levels in diabetic rats. MCE prevention significantly decreased levels of KW/BW, BUN, Cr, and 24 hr urinary protein. MCE inhibited glomerular basement membrane thickening, tubular epithelial cell hypertrophy, and glomerular capillary dilation. MCE also prevented the disappearance of bowman’s space and renal tubular lumen and decreased collagen deposition in rat kidney. Moreover, MCE reduced the levels of inflammatory factors (MCP-1 and TNF-α) and fibrosis factors (collagen IV and fibronectin).
Conclusion: MCE prevents DN through inhibition of inflammation and fibrosis in a rat model. It might provide a safe and effective way to prevent DN.
کلیدواژه‌ها
Diabetic nephropathy؛ Herb؛ Inflammation؛ Renal injury
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