Sohrabi, Reyhaneh, Pazgoohan, Nasim, Rezaei Seresht, Hasan, Amin, Bahareh. (1396). Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice. , 20(6), 708-714. doi: 10.22038/ijbms.2017.8841
Reyhaneh Sohrabi; Nasim Pazgoohan; Hasan Rezaei Seresht; Bahareh Amin. "Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice". , 20, 6, 1396, 708-714. doi: 10.22038/ijbms.2017.8841
Sohrabi, Reyhaneh, Pazgoohan, Nasim, Rezaei Seresht, Hasan, Amin, Bahareh. (1396). 'Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice', , 20(6), pp. 708-714. doi: 10.22038/ijbms.2017.8841
Sohrabi, Reyhaneh, Pazgoohan, Nasim, Rezaei Seresht, Hasan, Amin, Bahareh. Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice. , 1396; 20(6): 708-714. doi: 10.22038/ijbms.2017.8841

Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice

Iranian Journal of Basic Medical Sciences
مقاله 13، دوره 20، شماره 6، 2017، صفحه 708-714    اصل مقاله (1.24 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2017.8841
نویسندگان
Reyhaneh Sohrabi1؛ Nasim Pazgoohan1؛ Hasan Rezaei Seresht2؛ Bahareh Amin* 3
1Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran
2Traditional and Complementary Medicine Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
3Cellular and Molecular Research Center, Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
چکیده
Objective(s): The present study aimed to evaluate the putative antidepressant and anti-anxiety effects of the cinnamon essential oil when administered acute (for 3 doses) and sub-acute (for 14 days) to mice.
Materials and Methods: In an acute experimental study, forced swim test (FST) was conducted to evaluate the antidepressant-like behavior of animals treated with the intraperitoneal (IP) essential oil of cinnamon in triple doses (0.5, 1, and 2 mg/kg). In a sub-acute study (14 days in 24-hr intervals) antidepressant-like effects of essential oil (0.5, 1, and 2 mg/kg) with the same route were assessed in FST and tail suspension test (TST). Anti-anxiety and motor activities were evaluated using elevated plus-maze (EPM) and open field tests, respectively. Determination of different constituents within the sample oil was via gas chromatography–mass spectrometry (GC–MS) analysis.
Results: Repetitive administration of cinnamon essential oil (0.5, 1, 2 mg/kg) during 14 days significantly decreased the time of immobility in both FST and TST as compared to the control group. Mice treated with oil at the dose of 2 mg/kg spent a longer time and had more entries into the open arms of EPM as compared with the vehicle-treated ones. According to GC-MS analysis, 46 chemical compounds were identified in the studied cinnamon essential oil with the main constituent being trans-cinnamaldehyde (87.32%).
Conclusion: Cinnamon essential oil might be used as an adjunctive therapy in improving symptoms of depressive and anxiety disorders. However, dose-response effects need further evaluation. Trans-cinnamaldehyde might be responsible for the beneficial effect observed.
کلیدواژه‌ها
Cinnamon bark؛ Elevated plus maze Essential oil؛ Forced swimming test؛ Tail suspension test
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