Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 13، دوره 20، شماره 6، شهریور 2017، صفحه 708-714 اصل مقاله (1.24 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2017.8841 | ||
| نویسندگان | ||
| Reyhaneh Sohrabi1؛ Nasim Pazgoohan1؛ Hasan Rezaei Seresht2؛ Bahareh Amin* 3 | ||
| 1Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran | ||
| 2Traditional and Complementary Medicine Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran | ||
| 3Cellular and Molecular Research Center, Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran | ||
| چکیده | ||
| Objective(s): The present study aimed to evaluate the putative antidepressant and anti-anxiety effects of the cinnamon essential oil when administered acute (for 3 doses) and sub-acute (for 14 days) to mice. Materials and Methods: In an acute experimental study, forced swim test (FST) was conducted to evaluate the antidepressant-like behavior of animals treated with the intraperitoneal (IP) essential oil of cinnamon in triple doses (0.5, 1, and 2 mg/kg). In a sub-acute study (14 days in 24-hr intervals) antidepressant-like effects of essential oil (0.5, 1, and 2 mg/kg) with the same route were assessed in FST and tail suspension test (TST). Anti-anxiety and motor activities were evaluated using elevated plus-maze (EPM) and open field tests, respectively. Determination of different constituents within the sample oil was via gas chromatography–mass spectrometry (GC–MS) analysis. Results: Repetitive administration of cinnamon essential oil (0.5, 1, 2 mg/kg) during 14 days significantly decreased the time of immobility in both FST and TST as compared to the control group. Mice treated with oil at the dose of 2 mg/kg spent a longer time and had more entries into the open arms of EPM as compared with the vehicle-treated ones. According to GC-MS analysis, 46 chemical compounds were identified in the studied cinnamon essential oil with the main constituent being trans-cinnamaldehyde (87.32%). Conclusion: Cinnamon essential oil might be used as an adjunctive therapy in improving symptoms of depressive and anxiety disorders. However, dose-response effects need further evaluation. Trans-cinnamaldehyde might be responsible for the beneficial effect observed. | ||
| کلیدواژهها | ||
| Cinnamon bark؛ Elevated plus maze Essential oil؛ Forced swimming test؛ Tail suspension test | ||
| مراجع | ||
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