Almani, Suhail Ahmed, Memon, Iqbal Ahmed, Shaikh, Tariq Zaffar, Khoharo, Haji Khan, Ujjan, Ikramuddin. (1396). Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus. , 20(5), 511-515. doi: 10.22038/ijbms.2017.8675
Suhail Ahmed Almani; Iqbal Ahmed Memon; Tariq Zaffar Shaikh; Haji Khan Khoharo; Ikramuddin Ujjan. "Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus". , 20, 5, 1396, 511-515. doi: 10.22038/ijbms.2017.8675
Almani, Suhail Ahmed, Memon, Iqbal Ahmed, Shaikh, Tariq Zaffar, Khoharo, Haji Khan, Ujjan, Ikramuddin. (1396). 'Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus', , 20(5), pp. 511-515. doi: 10.22038/ijbms.2017.8675
Almani, Suhail Ahmed, Memon, Iqbal Ahmed, Shaikh, Tariq Zaffar, Khoharo, Haji Khan, Ujjan, Ikramuddin. Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus. , 1396; 20(5): 511-515. doi: 10.22038/ijbms.2017.8675

Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus

Iranian Journal of Basic Medical Sciences
مقاله 9، دوره 20، شماره 5، 2017، صفحه 511-515    اصل مقاله (971.32 K)
شناسه دیجیتال (DOI): 10.22038/ijbms.2017.8675
نویسندگان
Suhail Ahmed Almani1؛ Iqbal Ahmed Memon1؛ Tariq Zaffar Shaikh1؛ Haji Khan Khoharo* 2؛ Ikramuddin Ujjan3
1Department of Medicine Liaquat University of Medical and Health Sciences Jamshoro, Sindh, Pakistan
2Faculty of Medicine and Allied Medical Sciences Isra University, Hyderabad, Sindh, Pakistan
3Department of Pathology Liaquat University of Medical and Health Sciences Jamshoro, Sindh, Pakistan
چکیده
Objective(s): Causality of occurrence of metformin-associated lactic acidosis (MALA) is a clinical problem. Currently, there is no drug available to prevent MALA. The present study was conducted to evaluate the protective effect of Berberine (BBR) against MALA in induced diabetic rat model.
Materials and Methods: A sample of 75 healthy male Wistar rats was randomly selected according to inclusion and exclusion criteria. 75 male Wistar rats were randomly divided into a control and 4 experimental groups. Streptozotocin (STZ) in citrate buffer (pH 4.5) at a dose of 45 mg/kg was injected for induction of diabetes mellitus and rats achieving fasting blood glucose >250 mg/dl were included. Blood samples were collected 18 hr after the last dose of metformin and berberine. Ethical approval was taken before the study was conducted. Staistix 10.0 (USA) software was used for data analysis.
Results: Berberine decreased MALA. Metformin, metformin + BBR 50 mg/kg bwt, and metformin + BBR 100 mg/kg bwt showed serum lactate as 1.87±0.4 mmol/lL, 1.62 ± 0.44 mmol/l and 1.47± 0.45 mmol/l, respectively (P=0.0001).  Insulin resistance and liver enzymes were improved in BBR treated rats.
Conclusion: The present study reports berberine protects against MALA in streptozocin-induced diabetes mellitus.
کلیدواژه‌ها
Berberine؛ insulin resistance؛ Lactic acidosis؛ Metformin
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