Pharmacological effects of a synthetic quinoline, a hybrid of tomoxiprole and naproxen, against acute pain and inflammation in mice: a behavioral and docking study | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 14، دوره 20، شماره 4، تیر 2017، صفحه 446-450 اصل مقاله (1.05 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2017.8588 | ||
| نویسندگان | ||
| Hossein Hosseinzadeh1، 2؛ Fatemeh Mazaheri3؛ Razieh Ghodsi* 3، 4 | ||
| 1Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 4Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective(s): In the present study, we investigated the potential anti-nociceptive activity and acute anti-inflammatory effect of a synthetic quinoline compound (2-(4-Methoxyphenyl)benzo[h]quinoline-4-carboxylic acid, QC), possessing structural elements of both naproxen and tomoxiprole drugs. Materials and Methods: The anti-nociceptive activity of QC was evaluated using chemical- and thermal-induced nociception models and its acute anti-inflammatory effect was evaluated by xylene-induced ear edema test in mice. Results: QC displayed a dose dependent effect in both acute anti-nociceptive tests (writhing and hot plate). This compound at dose of 6.562 mg/kg showed a high anti-nociceptive effect near equal to diclofenac 5 mg/kg. It also showed high anti-inflammatory effects (less than 6.562 mg/kg) comparable to those of reference drugs diclofenac (5 mg/kg) and celecoxib (100 mg/kg). Docking study showed that this quinoline derivative could inhibit COX-2 enzyme strongly. Conclusion: QC showed high anti-nociceptive and anti-inflammatory effects comparable to reference drugs and can exert its anti-nociceptive and anti-inflammatory activities through COX-2 inhibition. | ||
| کلیدواژهها | ||
| Anti-inflammation؛ COX-2؛ Molecular modeling؛ Naproxen؛ NSAIDs؛ Quinoline؛ Tomoxiprole | ||
| مراجع | ||
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