Chronic Recurrent Multifocal Osteomyelitis in a 9-year-old Boy | ||
The Archives of Bone and Joint Surgery | ||
مقاله 12، دوره 5، شماره 3، مرداد 2017، صفحه 196-200 اصل مقاله (740.27 K) | ||
نوع مقاله: CASE REPORT | ||
شناسه دیجیتال (DOI): 10.22038/abjs.2017.8385 | ||
نویسندگان | ||
Abdolreza Malek1؛ Mohammadhassan Aelami2؛ Narges Afzali3؛ Ali Parsa4؛ Havva Jalalinia* 5 | ||
1Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
2Department of Pediatrics and Infection Control and Hand Hygiene Research Center, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
3Department of Radiology, Mashhad branch, Islamic Azad University, Mashhad, Iran | ||
4Department of Orthopedics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
5Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
چکیده | ||
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare aseptic, auto-inflammatory bone disorder. CRMO presents with bone pain with or without fever. The diagnosis of CRMO is a diagnosis of exclusion and should be included in the differential diagnosis of chronic inflammatory bone lesions in children. Cultures of the bone are typically sterile, antibiotic therapy does not result in clinical improvement whereas anti-inflammatory drugs improve the condition. Furthermore, biopsy should be considered in chronic and relapsing bone pain and swelling unresponsive to treatment. Herein, we present a nine-year-old boy complaining of recurrent pain in his upper and lower extremities. On examination he had mild fever and cervical lymphadenopathy. He also had experienced bone pain and weight loss in the recent month. Based on biopsy and bone scan he was finally diagnosed with CRMO. Naproxen and Pamidronate was prescribed and he was getting better and returned to normal life and activity without need to corticosteroids. | ||
کلیدواژهها | ||
Bone pain؛ Children؛ Chronic multifocal osteomyelitis (CRMO) | ||
مراجع | ||
1. Surendra G, Shetty U. Chronic recurrent multifocal osteomyelitis: a rare entity. J Med Imaging Radiat Oncol. 2015; 59(4):436-44. 2. Ferrari J, Pilkington C. Chronic recurrent multifocal osteomyelitis: the prevalence of lower-limb and foot involvement. J Am Podiatr Med Assoc. 2014; 104(6):583-7. 3. Bachmann F, Stieler K, Garcia Bartels N, Philipp S, Minden K, Blume-Peytavi U. Skin manifestations associated with chronic recurrent multifocal osteomyelitis in a 9-year-old girl. J Am Acad Dermatol. 2014; 71(5):e218-9. 4. Aygun D, Barut K, Camcioglu Y, Kasapcopur O. Chronic recurrent multifocal osteomyelitis: a rare skeletal disorder. BMJ Case Rep. 2015; 2015(10):bcr2015210061. 5. Watanabe T, Ono H, Morimoto Y, Otsuki Y, Shirai M, Endoh A, et al. Skull involvement in a pediatric case of chronic recurrent multifocal osteomyelitis. Nagoya J Med Sci. 2015; 77(3):493-500. 6. Alshammari A, Usmani S, Elgazzar AH, Ashkanani RA. Chronic recurrent multifocal osteomyelitis in children: a multidisciplinary approach is needed to establish a diagnosis. World J Nucl Med. 2013; 12(3):120-3. 7. Ferguson B, Gryfe D, Hsu W. Chronic recurrent multifocal osteomyelitis in a 13 year old female athlete: a case report. J Can Chiropr Assoc. 2013; 57(4):334-40. 8. Miettunen PM, Wei X, Kaura D, Reslan WA, Aguirre AN, Kellner JD. Dramatic pain relief and resolution of bone inflammation following pamidronate in 9 pediatric patients with persistent chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J. 2009; 12(7):2–15. 9. Fergson PJ, Laxer RM. Autoinflammatory bone disorders. In: Cassidy JT, Petty RE, Laxer RM, Lindsley CB, editors. Textbook of pediatric rheumatology. 7th ed. New York: Elsevier Health Sciences; 2016. 10. Aelami M, Ahanchian H, Esfahani RJ, Davoudi Y, Gharedaghi M, Dabbagh Kakhki VR. Chronic recurrent multifocal osteomyelitis; manifestation, imaging and diagnosis. Iran J Nucl Med. 2014; 22(1):29-32. 11. Borzutzky A, Stern S, Reiff A, Zurakowski D, Steinberg EA, Dedeoglu F, et al. Pediatric chronic nonbacterial osteomyelitis. Pediatrics. 2012; 130(5):e1190-7. 12. Jansson A, Renner ED, Ramser J, Mayer A, Haban M, Meindl A, et al. Classification of non-bacterial osteitis: retrospective study of clinical, immunological andgenetic aspects in 89 patients. Rheumatology (Oxford). 2007; 46(1):154-60. 13. Costa-Reis P, Sullivan KE. Chronic recurrent multifocal osteomyelitis. J Clin Immunol. 2013; 33(6):1043-56. 14. Assari R, Ziaee V, Ahmadinejad Z, Vasei M, Moradinejad MH. Caseous granuloma: tuberculosis or chronic recurrent multifocal osteomyelitis? Iran J Pediatr. 2014; 24(6):770-4. 15. Ferguson PJ, Sandu M. Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. Curr Rheumatol Rep. 2012; 14(2):130-41. | ||
آمار تعداد مشاهده مقاله: 1,033 تعداد دریافت فایل اصل مقاله: 1,271 |