Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 15، دوره 20، شماره 3، خرداد 2017، صفحه 334-337 اصل مقاله (972.86 K) | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2017.8364 | ||
| نویسندگان | ||
| Gholam Hossein Farjah* 1؛ Shadi Salehi2؛ Mohammad Hasan Ansari3؛ Bagher Pourheidar1 | ||
| 1Neurophysiology Research Center, Department of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran | ||
| 2Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran | ||
| 3Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran | ||
| چکیده | ||
| Objective(s): Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. Results: The mean motor deficit index (MDI) scores were significantly lower in the saffron extract groups than in the NS group at 48 hr after spinal cord ischemia (P<0.001). Saffron extract groups significantly decreased plasma level of malondialdehyde than in the NS Group (P<0.05). The number of motor normal neurons was significantly greater in the high saffron extract group than in the NS and low saffron group (P<0.05). Conclusion: These data suggest that a saffron extract may protect spinal cord neurons from I/R injury. | ||
| کلیدواژهها | ||
| Ischemia؛ Reperfusion؛ Spinal Cord؛ Saffron extract | ||
| مراجع | ||
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