The effect of caffeine on orthodontic tooth movement in rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 5، دوره 20، شماره 3، خرداد 2017، صفحه 260-264 اصل مقاله (1008.24 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2017.8353 | ||
| نویسندگان | ||
| Mohsen Shirazi1، 2؛ Hamed Vaziri3؛ Behzad Salari4؛ Pouria Motahhari5؛ Shahroo Etemad-Moghadam1؛ Ahmad Reza Dehpour* 6، 7 | ||
| 1Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran | ||
| 2Department of Orthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran | ||
| 3Private practice, Houston, Texas | ||
| 4Orthodontic Resident, Department of Orthodontics, School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran | ||
| 5Department of Oral and Maxillofacial Pathology, Tehran University of Medical Sciences, Tehran, Iran | ||
| 6Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran | ||
| 7Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Objective(s): to determine the effect of different doses of caffeine on orthodontic tooth movement (OTM) in rats. Materials and Methods: Forty male 250-300 g Sprague-Dawley rats were randomly divided into four groups of ten animals each and received 0 (control), 1 g/l, 2 g/l and 3 g/l caffeine in tap water for 3 days. Orthodontic appliances were ligated between the maxillary first molars and incisors on the 4th day of the study period. All rats were sacrificed after 2 weeks of treatment after which OTM was measured. Hematoxylin/eosin-stained sections of the molars were prepared and the mesial roots were examined for resorption-lacunae depth and osteoclast number. ANOVA was used for statistical analysis (P<0.05). Results: A significant decrease in OTM was observed only in the 2 g/l (P=0.043) and 3 g/l (P<0.01) caffeine-receiving rats compared to the control animals. Osteoclast counts and resorption-lacunae depths demonstrated significant differences between each of the caffeine groups and control rats (P<0.05). None of the variables showed significant differences between the caffeine groups (P>0.05). Conclusion: According to our findings, one of the effects of caffeine consumption during orthodontic treatment in rats was decreased root resorption. Additionally, concentrations of 2 g/l and 3 g/l inhibited OTM which seems to be due to its influence on osteoclast numbers. | ||
| کلیدواژهها | ||
| Caffeine؛ Rats؛ root resorption؛ Tooth movement | ||
| مراجع | ||
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