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Moshiri, Mohammad, Moallem, Seyed Adel, Attaranzadeh, Armin, Saberi, Zahra, Etemad, Leila. (1395). Injury to skeletal muscle of mice following acute and sub-acute pregabalin exposure. , 20(3), 256-259. doi: 10.22038/ijbms.2017.8352
Mohammad Moshiri; Seyed Adel Moallem; Armin Attaranzadeh; Zahra Saberi; Leila Etemad. "Injury to skeletal muscle of mice following acute and sub-acute pregabalin exposure". , 20, 3, 1395, 256-259. doi: 10.22038/ijbms.2017.8352
Moshiri, Mohammad, Moallem, Seyed Adel, Attaranzadeh, Armin, Saberi, Zahra, Etemad, Leila. (1395). 'Injury to skeletal muscle of mice following acute and sub-acute pregabalin exposure', , 20(3), pp. 256-259. doi: 10.22038/ijbms.2017.8352
Moshiri, Mohammad, Moallem, Seyed Adel, Attaranzadeh, Armin, Saberi, Zahra, Etemad, Leila. Injury to skeletal muscle of mice following acute and sub-acute pregabalin exposure. , 1395; 20(3): 256-259. doi: 10.22038/ijbms.2017.8352

Injury to skeletal muscle of mice following acute and sub-acute pregabalin exposure

Iranian Journal of Basic Medical Sciences
مقاله 4، دوره 20، شماره 3، خرداد 2017، صفحه 256-259    اصل مقاله (1.05 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2017.8352
نویسندگان
Mohammad Moshiri1، 2؛ Seyed Adel Moallem3؛ Armin Attaranzadeh4؛ Zahra Saberi5؛ Leila Etemad* 6
1Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran
3Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
4Milad Infertility Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
5Nanotechnology Research Center School of Pharmacy, Mashhad University Medical Sciences, Mashhad, Iran
6Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s): Pregabalin (PGB) is a new antiepileptic drug that has received FDA approval for patient who suffers from central neuropathic pain, partial seizures, generalized anxiety disorder, fibromyalgia and sleep disorders. This study was undertaken to evaluate the possible adverse effects of PGB on the muscular system of mice.
Materials and Methods: To evaluate the effect of PGB on skeletal muscle, the animals were exposed to a single dose of 1, 2 or 5 g /kg or daily doses of 20, 40 or 80 mg/kg for 21 days, intraperitoneally (IP). Twaenty-four hr after the last drug administration, all animals were sacrificed. The level of fast-twitch skeletal muscle troponin I and CK-MM activity were evaluated in blood as an indicator of muscle injury. Skeletal muscle pathological findings were also reported as scores ranging from 1 to 3 based on the observed lesion.
Results: In the acute and sub-acute toxicity assay IP injection of PGB significantly increased the activity and levels of CK-MM and fsTnI compared to the control group. Sub-acute exposure to PGB caused damages that include muscle atrophy, infiltration of inflammatory cells and cell degeneration.
Conclusion: PGB administration especially in long term care causes muscle atrophy with infiltration of inflammatory cells and cell degeneration. The fsTnI and CK-MM are reliable markers in PGB-related muscle injury. The exact mechanisms behind the muscular damage are unclear and necessitate further investigations.
کلیدواژه‌ها
Acute؛ Muscle injury؛ Pregabalin؛ Skeletal muscle؛ Subacute
مراجع

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