Otitis Media with Effusion in Children and the Impact of Risk Factors on Serum Cytokine Levels | ||
| Iranian Journal of Otorhinolaryngology | ||
| مقاله 3، دوره 29، شماره 2، خرداد 2017، صفحه 75-81 اصل مقاله (309.97 K) | ||
| نوع مقاله: Original | ||
| شناسه دیجیتال (DOI): 10.22038/ijorl.2017.14410.1513 | ||
| نویسندگان | ||
| Saba Arshi1؛ Fatemeh Dehghani-Firouzabadi* 2؛ Babak Ghalehbaghi3؛ Ali Dehghani-Firouzabadi4؛ Farhad Jalali1؛ Mehdi Shekarabi1؛ Reza Sirous5؛ Mohammad Dehghani-Firouzabadi2 | ||
| 1Department of Allergy and Clinical Immunology, Iran University of Medical Sciences, Tehran, Iran. | ||
| 2ENT and Head and Neck Research Center and Department, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences,Tehran,Iran. | ||
| 3ENT and Head and Neck Research Center and Department, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences,Tehran,Iran. | ||
| 4Department of Health, Epidemiologist, Mississippi State, United States. | ||
| 5Department of Radiology, University of Mississippi Medical Center, Mississippi State, United States. | ||
| چکیده | ||
| Introduction: To evaluate the role of allergic-type and infectious-type cytokines in children with chronic otitis media with effusion (OME) Materials and Methods: We investigated serum levels of interleukins (IL)-4, IL-5, and IL-13, along with interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α), by enzyme-linked immunosorbent assay (ELISA) in 35 children with OME and 28 healthy controls. Results: Children with OME had significantly higher levels of IL-5 in comparison with the control group, ranging from 1 pg/ml in cases to 0.04 pg/ml in controls (P=0.009). However, after adjusting for confounding variables, there was no significant difference in serum levels of IL-13, IL-4, IFN-γ, or TNF-α between the two groups (P=0.287, P=0.627, P=0.793, and P=0.217, respectively) Conclusions: The findings of this study suggest that in comparison with the control group, serum IL-5 levels were elevated in OME cases. | ||
| کلیدواژهها | ||
| Interleukins؛ Inflammatory cytokines؛ Otitis media with effusion؛ Pediatrics | ||
| مراجع | ||
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