Toxicology effects of saffron and its constituents: a review | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 2، دوره 20، شماره 2، اردیبهشت 2017، صفحه 110-121 اصل مقاله (1.52 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2017.8230 | ||
| نویسندگان | ||
| Hasan Badie Bostan1؛ Soghra Mehri1، 2، 3؛ Hossein Hosseinzadeh* 1، 2 | ||
| 1Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Neurocognitive Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Saffron (Crocus sativus L.) has been considered as a medicinal plant since ancient times and also widely used as food additive for its color, taste and odor. The pharmacological properties of saffron and its main constituents, crocin and safranal have been evaluated using different in vivo and in vitro models. Additionally, other lines of studies have found toxicological effects of saffron. However, a comprehensive review that covers all aspects of its toxicity has not been published yet. The current study provides classified information about the toxic effects of saffron and its constituents in various exposure conditions including acute, sub-acute, sub-chronic and chronic studies. Therapeutic doses of saffron exhibits no significant toxicity in both clinical and experimental investigations. | ||
| کلیدواژهها | ||
| Crocetin؛ Crocin؛ Saffron؛ Safranal؛ Toxicity | ||
| مراجع | ||
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