HIV-1/HTLV Co-Infection: a Survey of Molecular Basis with Clinical Studies | ||
| Journal of Patient Safety & Quality Improvement | ||
| مقاله 6، دوره 5، شماره 1، فروردین 2017، صفحه 497-501 اصل مقاله (215.04 K) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22038/psj.2017.9739.1093 | ||
| نویسندگان | ||
| Marzieh Saberi* 1؛ Ashraf Tavanaii sani2 | ||
| 1Department of Infectious Disease, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 2Department of Infectious Disease, Imam Reza Hospital, Mashhad University of medical sciences, Mashhad, Iran. | ||
| چکیده | ||
| Human immunodeficiency virus type-1 (HIV–1) and human T-cell leukemia virus (HIV-1/HTLV) co-infection is a serious health problem worldwide, especially in endemic areas and vulnerable subjects like intravenous drug abusers. This is due to the fact that CD4+ and CD8+ T-cells are the primary targets of HTLV-1 and HTLV-2, respectively. The influence of HTLV-1 and HTLV-2 on CD4+ count can shortened or prolong progression to AIDS and the development of more clinical complications. Opportunistic infections may differ between HIV-1/HTLV-1 and HIV-1/HTLV-2 co-infection subjects. Several epidemiologic studies have discussed molecular bases of HIV-1/HTLV co-infection, including cytokine and chemokine mediated pathways; however, they have yielded discrepant results. | ||
| کلیدواژهها | ||
| Co-infection؛ HIV؛ HTLV-1 | ||
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