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Kamiya, Yoshito, Ota, Satoru, Okumiya, Shintaro, Yamashita, Kosuke, Takaki, Akihiro, Ito, Shigeki. (1395). Uptake index of 123I-metaiodobenzylguanidine myocardial scintigraphy for diagnosing Lewy body disease. , 5(1), 37-43. doi: 10.22038/aojnmb.2016.7972
Yoshito Kamiya; Satoru Ota; Shintaro Okumiya; Kosuke Yamashita; Akihiro Takaki; Shigeki Ito. "Uptake index of 123I-metaiodobenzylguanidine myocardial scintigraphy for diagnosing Lewy body disease". , 5, 1, 1395, 37-43. doi: 10.22038/aojnmb.2016.7972
Kamiya, Yoshito, Ota, Satoru, Okumiya, Shintaro, Yamashita, Kosuke, Takaki, Akihiro, Ito, Shigeki. (1395). 'Uptake index of 123I-metaiodobenzylguanidine myocardial scintigraphy for diagnosing Lewy body disease', , 5(1), pp. 37-43. doi: 10.22038/aojnmb.2016.7972
Kamiya, Yoshito, Ota, Satoru, Okumiya, Shintaro, Yamashita, Kosuke, Takaki, Akihiro, Ito, Shigeki. Uptake index of 123I-metaiodobenzylguanidine myocardial scintigraphy for diagnosing Lewy body disease. , 1395; 5(1): 37-43. doi: 10.22038/aojnmb.2016.7972

Uptake index of 123I-metaiodobenzylguanidine myocardial scintigraphy for diagnosing Lewy body disease

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 6، دوره 5، شماره 1، فروردین 2017، صفحه 37-43    اصل مقاله (1.08 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/aojnmb.2016.7972
نویسندگان
Yoshito Kamiya1؛ Satoru Ota2؛ Shintaro Okumiya2؛ Kosuke Yamashita3؛ Akihiro Takaki4؛ Shigeki Ito* 5
1Graduate School of Health Sciences, Kumamoto University, Kuhonji 4-24-1, Chuo-ku, Kumamoto 862-0796, Japan
2Graduate School of Health Sciences, Kumamoto University
3Fujifilm RI Pharma Co.,Ltd.
4Faculty of Life Sciences, Kumamoto University,
5Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University, Kuhonji 4-24-1, Kumamoto 862-0796, Japan
چکیده
Objective(s): Iodine-123 metaiodobenzylguanidine (123I-MIBG) myocardial scintigraphy has been used to evaluate cardiac sympathetic denervation in Lewy body disease (LBD), including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). The heart-tomediastinum ratio (H/M) in PD and DLB is significantly lower than that in Parkinson’s plus syndromes and Alzheimer’s disease. Although this ratio is useful for distinguishing LBD from non-LBD, it fluctuates depending on the system performance of the gamma cameras. Therefore, a new, simple quantification method using 123I-MIBG uptake analysis is required for clinical study. The purpose of this study was to develop a new uptake index with a simple protocol to determine 123I-MIBG uptake on planar images.
Methods: The 123I-MIBG input function was obtained from the input counts of the pulmonary artery (PA), which were assessed by analyzing the PA time-activity curves. The heart region of interest used for determining the H/M was used for calculating the uptake index, which was obtained by dividing the heart count by the input count.
Results: Forty-eight patients underwent 123I-MIBG chest angiography and planar imaging, after clinical feature assessment and tracer injection. The H/M and 123I-MIBG uptake index were calculated and correlated with clinical features. Values for LBD were significantly lower than those for non-LBD in all analyses (P<0.001). The overlapping ranges between non-LBD and LBD were 2.15 to 2.49 in the H/M method, and 1.04 to 1.22% in the uptake index method. The diagnostic accuracy of the uptake index (area under the curve (AUC), 0.98; sensitivity, 96%; specificity, 91%; positive predictive value (PPV), 90%; negative predictive value (NPV), 93%; and accuracy, 92%) was approximately equal to that of the H/M (AUC, 0.95; sensitivity, 93%; specificity, 91%; PPV, 90%; NPV, 93%; and accuracy, 92%) for discriminating patients with LBD and non-LBD.
Conclusion: A simple uptake index method was developed using 123I-MIBG planar imaging and the input counts determined by analyzing chest radioisotope angiography images of the PA. The diagnostic accuracy of the uptake index was approximately equal to that of the H/M for discriminating patients with LBD and non-LBD.
کلیدواژه‌ها
Iodine-123 metaiodobenzylguanidine؛ Quantification؛ Uptake index؛ Lewy body disease
مراجع
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