Carthamus tinctorius L. ameliorates brain injury followed by cerebral ischemia-reperfusion in rats by antioxidative and anti-inflammatory mechanisms | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 15، دوره 19، شماره 12، اسفند 2016، صفحه 1368-1375 اصل مقاله (1.35 M) | ||
| نوع مقاله: Short Communication | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2016.7925 | ||
| نویسندگان | ||
| Pin-Kuei Fu1؛ Tai-Long Pan2، 3؛ Chi-Yu Yang4؛ Kee-Ching Jeng5؛ Nou-Ying Tang6؛ Ching-Liang Hsieh* 7، 8، 9 | ||
| 1Department of Critical Care Medicine, Taichung Veterans General Hospital, Taichung, 40705, Taiwan | ||
| 2School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan | ||
| 3Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan | ||
| 4Animal Technology Laboratory, Agriculture Technology Research Institute, Miaoli, Taiwan | ||
| 5Department of Medical Research, Tungs’ Taichung MetroHarbor Hospital, Taichung 43503, Taiwan | ||
| 6School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan | ||
| 7Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung, Taiwan | ||
| 8Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan | ||
| 9Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan | ||
| چکیده | ||
| Objective(s): Carthamus tinctorius L. (CT) or saffloweris widely used in traditional Chinese medicine. This study investigated the effects of CT extract (CTE) on ischemia–reperfusion (I/R) brain injury and elucidated the underlying mechanism. Materials and Methods: The I/R model was conducted by occlusion of both common carotid arteries and right middle cerebral artery for 90 min followed by 24 hr reperfusion in Sprague-Dawley rats. CTE (0.2-0.6 g/kg) was administered intraperitoneally before and during ischemia, and during reperfusion period. The cerebral infarction area, neurological deficit scores, free radicals (lucigenin chemiluminescence counts) and pro-inflammatory cytokines expression were measured. Results: Pretreatment and treatment with CTE significantly reduced the cerebral infarction area and neurological deficits. CTE (0.4 g/kg) also reduced blood levels of free radicals and expression of tumor necrosis factor-α and interleukin-1β in the cerebral infarction area. Conclusion: The reduction in I/R cerebral infarction caused by CTE is possibly associated with its antioxidation and anti-inflammatory properties. | ||
| کلیدواژهها | ||
| Carthamus tinctorius extract؛ Free radicals؛ Ischemia-reperfusion injury | ||
| مراجع | ||
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