Diagnostic Performance and Safety of Positron Emission Tomography Using 18F-Fluciclovine in Patients with Clinically Suspected High- or Low-grade Gliomas: A Multicenter Phase IIb Trial | ||
| Asia Oceania Journal of Nuclear Medicine and Biology | ||
| مقاله 3، دوره 5، شماره 1، فروردین 2017، صفحه 10-21 اصل مقاله (1.62 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/aojnmb.2016.7869 | ||
| نویسندگان | ||
| Toshihiko Wakabayashi1؛ Toshihiko Iuchi2؛ Naohiro Tsuyuguchi3؛ Ryo Nishikawa4؛ Yoshiki Arakawa5؛ Takashi Sasayama6؛ Keisuke Miyake7؛ Tadashi Nariai8؛ Yoshitaka Narita9؛ Naoya Hashimoto10؛ Osamu Okuda11؛ Hiroshi Matsuda12؛ Kazuo Kubota13؛ Kimiteru Ito14؛ Yoichi Nakazato15؛ Kan Kubomura* 16 | ||
| 1Department of Neurosurgery, Nagoya University, Graduate School of Medicine | ||
| 2Division of Neurological Surgery, Chiba Cancer Center | ||
| 3Department of Neurosurgery, Osaka City University Graduate School of Medicine | ||
| 4Department of Neuro-Oncology/Neurosurgery, Saitama International Medical Center, Saitama Medical University | ||
| 5Department of Neurosurgery, Kyoto University Graduate School of Medicine | ||
| 6Department of Neurosurgery, Kobe University Graduate School of Medicine | ||
| 7Department of Neurological Surgery, Faculty of Medicine, Kagawa University | ||
| 8Department of Neurosurgery, Tokyo Medical and Dental University | ||
| 9Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital | ||
| 10Department of Neurosurgery, Osaka University Graduate School of Medicine | ||
| 11Department of Neurosurgery, Juntendo Tokyo Koto Geriatric Medical Center | ||
| 12Integrative Brain Imaging Center, National Center of Neurology and Psychiatry | ||
| 13Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine | ||
| 14Department of Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology | ||
| 15Department of Pathology, Hidaka Hospital | ||
| 16Clinical Development Department, Nihon Medi-Physics Co., Ltd. | ||
| چکیده | ||
| Objective(s): The study objective was to assess the diagnostic performance of positron emission tomography (PET) for gliomas using the novel tracer 18F-fluciclovine (anti-[18F]FACBC) and to evaluate the safety of this tracer in patients with clinically suspected gliomas. Methods: Anti-[18F]FACBC was administered to 40 patients with clinically suspected high- or low-grade gliomas, followed by PET imaging. T1-weighted, contrast-enhanced T1-weighted, and fluid-attenuated inversion recovery (or T2-weighted) magnetic resonance imaging (MRI) scans were obtained to plan for the tissue collection. Tissues were collected from either “areas visualized using anti-[18F]FACBC PET imaging but not using contrast-enhanced T1-weighted imaging” or “areas visualized using both anti-[18F]FACBC-PET imaging and contrast-enhanced T1-weighted imaging” and were histopathologically examined to assess the diagnostic accuracy of anti-[18F]FACBC-PET for gliomas. Results: The positive predictive value of anti-[18F]FACBC-PET imaging for glioma in areas visualized using anti-[18F]FACBC-PET imaging, but not visualized using contrast-enhanced T1- weighted images, was 100.0% (26/26), and the value in areas visualized using both contrastenhanced T1-weighted imaging and anti- [18F]FACBC-PET imaging was 87.5% (7/8). Twelve adverse events occurred in 7 (17.5%) of the 40 patients who received anti-[18F]FACBC. Five events in five patients were considered to be adverse drug reactions; however, none of the events were serious, and all except one resolved spontaneously without treatment. Conclusion: This Phase IIb trial showed that anti-[18F]FACBC-PET imaging was effective for the detection of gliomas in areas not visualized using contrast-enhanced T1-weighted MRI and the tracer was well tolerated. | ||
| کلیدواژهها | ||
| Clinical trial؛ 18F-fluciclovine؛ Glioma؛ Positron Emission Tomography؛ brain tumor | ||
| مراجع | ||
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