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Tyagita, Nurina, Nasihun, Taufiqurrachman, Sumarawati, Titiek. (1395). The Comparative Effect of Fasting with and without Caloric Restriction in Rat on Oxidative Stress Parameters. , 4(3), 102-107. doi: 10.22038/jfh.2016.7788
Nurina Tyagita; Taufiqurrachman Nasihun; Titiek Sumarawati. "The Comparative Effect of Fasting with and without Caloric Restriction in Rat on Oxidative Stress Parameters". , 4, 3, 1395, 102-107. doi: 10.22038/jfh.2016.7788
Tyagita, Nurina, Nasihun, Taufiqurrachman, Sumarawati, Titiek. (1395). 'The Comparative Effect of Fasting with and without Caloric Restriction in Rat on Oxidative Stress Parameters', , 4(3), pp. 102-107. doi: 10.22038/jfh.2016.7788
Tyagita, Nurina, Nasihun, Taufiqurrachman, Sumarawati, Titiek. The Comparative Effect of Fasting with and without Caloric Restriction in Rat on Oxidative Stress Parameters. , 1395; 4(3): 102-107. doi: 10.22038/jfh.2016.7788

The Comparative Effect of Fasting with and without Caloric Restriction in Rat on Oxidative Stress Parameters

Journal of Nutrition,Fasting and Health
مقاله 6، دوره 4، شماره 3، آذر 2016، صفحه 102-107    اصل مقاله (361.24 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/jfh.2016.7788
نویسندگان
Nurina Tyagita* 1؛ Taufiqurrachman Nasihun2؛ Titiek Sumarawati3
1Medical Faculty of Islamic University Sultan Agung Semarang
2Biochemistry Department Medicine Faculty of Sultan Agung Islamic University Semarang Jl. Raya Kaligawe Km. 4 PO.Box 1054, Semarang, Central Java- Indonesia, 50112
3Human’s Health and Aging Science Biomedic Master Degree Medicine Faculty of Sultan Agung Islamic University Semarang Jl. Raya Kaligawe Km. 4 PO.Box 1054, Semarang, Central Java- Indonesia, 50112
چکیده
Introduction: Fasting, like Islamic Ramadan Fasting, has been associated with health benefits. Islamic Ramadan fasting, a form of caloric restriction (CR) or alternate day fasting that. Studies suggest a comparable effect of ADF and caloric restriction. Despite the fact that fasting can be considered as a form of dietary restriction, fasters tend to have difficulty to reduce their food intake during non-fasting period by overeating leading to the excessive calorie intake. To compare the effect of fasting with and without caloric restriction in Sprague Dawley rats. Methods: The rats were assigned to one of three groups: ADF with 70 % calorie intake (30% CR), ADF with 100 % calorie intake (0% CR), and ADF with 140 % calorie intake (excessive calorie intake) and AL (fed ad libitum). All groups were subjected to 6 hour fasting per day (9 a.m. until 3 p.m.) or 15 days. The plasma sample was taken for MDA level assessment. Urinary 8-oxodG levels were determined by using ELISA. Results: ADF with 30% calorie restriction (F70) group had the lowest MDA level. Measurement of 8-oxodG level showed that group F70 had the highest production of 8-oxodG. There was an inverse relationship between MDA level and 8-oxodG level meaning the lower MDA level, the lower 8-oxodG levels were produced. Conclusion: ADF fasting with 30% caloric restriction reduce the MDA level but increase 8-oxodG levels. This study suggest the beneficial effect of fasting requires decrease in overall caloric intake.
کلیدواژه‌ها
Alternate day fasting؛ Caloric restriction؛ Oxidative stress
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