Capparis spinosa L. aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic mice | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 164، دوره 7، شماره 2، خرداد و تیر 2017، صفحه 191-198 اصل مقاله (399.82 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2016.7761 | ||
| نویسندگان | ||
| Mohamed Eddouks* 1؛ Ahmed Lemhadri1؛ Morad Hebi1؛ Ahmed EL Hidani1؛ Naoufel Ali Zeggwagh2؛ Bachir EL Bouhali1؛ Lhoussaine Hajji1؛ Remy Burcelin3 | ||
| 1Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco | ||
| 2ISPITS Rabat, Avenue Hassan II Km 4,5 Route de Casa, Rabat Maroc | ||
| 32UMR 5018 CNRS-UPS and IFR 31, Rangueil Hospital, L1 Bldg, BP 84225 Toulouse 31432 Cedex 4, France | ||
| چکیده | ||
Objective: As the aqueous extract of Capparis spinosa (CS) possess antidiabetic effect, he present study aims to reveal the possible mechanism of action of CS in diabetic mice. Materials and Methods: Both single and repeated oral administrations of aqueous extract of CS were performed in multi-low dose streptozotocin-induced (MLDS) diabetic mice. Euglycemic hyperinsulinemic clamp was used in association with the endogenous glucose production (perfusion rate of 3-3H glucose) to evaluate the effect of CS aqueous extract on insulin sensitivity. Results: Our study showed that aqueous extract of CS possess a potent hypoglycaemic activity in MLDS diabetic mice. Furthermore, the analysis perfusion of 3-3H glucose demonstrated the parallel decrease of basal endogenous glucose production (EGP) with the hypoglycaemic activity. EGP was lower in CS-Treated group when compared to the control group (p<0.001). The euglycemic hyperinsulinemic clamp technique demonstrated that CS treatment improves insulin sensitivity in peripheral tissues. Conclusion: We conclude that the antihyperglycemic effet CS is probably due to the inhibition of basal endogenous glucose production and the improvement of insulin sensitivity in MLDS diabetic mice. | ||
| کلیدواژهها | ||
| Diabetes؛ Streptozotocin؛ Insulin sensitivity؛ Mice | ||
| مراجع | ||
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