Preventive effect of Coriandrum sativum on neuronal damages in pentylentetrazole-induced seizure in rats | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 4، دوره 7، شماره 2، خرداد و تیر 2017، صفحه 116-128 اصل مقاله (1.08 M) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2016.7757 | ||
| نویسندگان | ||
| Mojtaba Pourzaki1؛ Mansour Homayoun2؛ Saeed Sadeghi1؛ Masoumeh seghatoleslam* 3؛ Mahmoud Hosseini4؛ Alireza Ebrahimzadeh Bideskan5 | ||
| 1Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Microanatomy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 4Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 5Department of Anatomy and Cell Biology, Microanatomy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
Objective:Coriandrum sativum (C. sativum) as a medicinal plant has been pointed to have analgesic, hypnotic and anti-oxidant effects. In the current study, a possible preventive effect of the hydro-alcoholic extract of the plant on neuronal damages was examined in pentylenetetrazole (PTZ) rat model of seizure. Materials and Methods: Forty male rats were divided into five main groups and treated by (1) saline, (2) PTZ: 100 mg/kg PTZ (i.p) and (3-5) 50, 100 and 200 mg/kg of hydro-alcoholic extract of C. sativum during seven consecutive days before PTZ injection. After electrocorticography (ECoG), the brains were removed to use for histological examination. Results: All doses of the extract reduced duration, frequency and amplitude of the burst discharges while prolonged the latency of the seizure attacks (p<0.05, p<0.01, and p<0.001). Administration of all 3 doses of the extract significantly prevented from production of dark neurons (p<0.01, and p<0.001) and apoptotic cells (p<0.05, p<0.01, and p<0.001) in different areas of the hippocampus compared to PTZ group. Conclusion: The results of this study allow us to conclude that C. sativum,because of its antioxidant properties, prevents from neuronal damages in PTZ rat model of seizure. | ||
| کلیدواژهها | ||
| Coriandrum sativum؛ Seizure؛ Apoptosis؛ Neuronal damage؛ Hippocampus | ||
| مراجع | ||
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