Association of IL-10 Gene Polymorphisms and Human T Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran (Mashhad) | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 15، دوره 16، شماره 3، خرداد 2013، صفحه 258-263 اصل مقاله (227.46 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2013.743 | ||
| نویسندگان | ||
| Abbas Shirdel1؛ Mahmoud Reza Azarpazhooh2؛ Maryam Sahebari3؛ Mohsen Ghanbari4؛ Seyedeh Zahra Mirfeizi3؛ Ian Hutchinson5؛ Aghigh Ziaee4؛ Houshang Rafatpanah6 | ||
| 1Department of Hematology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Neurology Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 4Immunology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 5Immunology Research Group, Faculty of Life Sciences, The University of Manchester, United Kingdom | ||
| 6Inflammation and Inflammatory Disease Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| The underlying mechanisms leading to the development of human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals are not fully understood. Host genetic factors appear to be involved as risk factors for developing HAM/TSP. We investigated the possible contribution of interleukin-10 (IL-10) as a risk factor to HAM/TSP by comparing frequencies of promoter region single nucleotide polymorphisms in HTLV-I infected Iranian patients who either remained asymptomatic or developed HAM/TSP and asymptomatic HTLV-I carriers. Healthy, uninfected individuals from the same region served as healthy controls. Significant differences were observed in the distribution of IL-10 promoter alleles and genotypes at position -819 and -592 between HAM/TSP patients and healthy controls (P=0.01), and between HTLV-I carriers and healthy controls (P=0.02). The frequency of the low IL-10 producer haplotype (-1082*A, -819*T, -592*A) was significantly associated with HTLV-I carriage or HAM/TSP compared with healthy controls (P= 0.02 and 0.01, respectively). Our results suggest that IL-10 -819*T and -592*A alleles are significant risk factors for developing HTLLV-I infection but do not appear to convey additional risk for developing HAM/TSP | ||
| کلیدواژهها | ||
| Gene HAM/TSP HTLV-I IL-10 Polymorphisms | ||
| مراجع | ||
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