Shirdel, Abbas, Azarpazhooh, Mahmoud Reza, Sahebari, Maryam, Ghanbari, Mohsen, Mirfeizi, Seyedeh Zahra, Hutchinson, Ian, Ziaee, Aghigh, Rafatpanah, Houshang. (1391). Association of IL-10 Gene Polymorphisms and Human T Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran (Mashhad). , 16(3), 258-263. doi: 10.22038/ijbms.2013.743
Abbas Shirdel; Mahmoud Reza Azarpazhooh; Maryam Sahebari; Mohsen Ghanbari; Seyedeh Zahra Mirfeizi; Ian Hutchinson; Aghigh Ziaee; Houshang Rafatpanah. "Association of IL-10 Gene Polymorphisms and Human T Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran (Mashhad)". , 16, 3, 1391, 258-263. doi: 10.22038/ijbms.2013.743
Shirdel, Abbas, Azarpazhooh, Mahmoud Reza, Sahebari, Maryam, Ghanbari, Mohsen, Mirfeizi, Seyedeh Zahra, Hutchinson, Ian, Ziaee, Aghigh, Rafatpanah, Houshang. (1391). 'Association of IL-10 Gene Polymorphisms and Human T Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran (Mashhad)', , 16(3), pp. 258-263. doi: 10.22038/ijbms.2013.743
Shirdel, Abbas, Azarpazhooh, Mahmoud Reza, Sahebari, Maryam, Ghanbari, Mohsen, Mirfeizi, Seyedeh Zahra, Hutchinson, Ian, Ziaee, Aghigh, Rafatpanah, Houshang. Association of IL-10 Gene Polymorphisms and Human T Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran (Mashhad). , 1391; 16(3): 258-263. doi: 10.22038/ijbms.2013.743

Association of IL-10 Gene Polymorphisms and Human T Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran (Mashhad)

Iranian Journal of Basic Medical Sciences
مقاله 15، دوره 16، شماره 3، 2013، صفحه 258-263    اصل مقاله (227.46 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2013.743
نویسندگان
Abbas Shirdel1؛ Mahmoud Reza Azarpazhooh2؛ Maryam Sahebari3؛ Mohsen Ghanbari4؛ Seyedeh Zahra Mirfeizi3؛ Ian Hutchinson5؛ Aghigh Ziaee4؛ Houshang Rafatpanah6
1Department of Hematology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Neurology Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4Immunology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5Immunology Research Group, Faculty of Life Sciences, The University of Manchester, United Kingdom
6Inflammation and Inflammatory Disease Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
 
The underlying mechanisms leading to the development of human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals are not fully understood. Host genetic factors appear to be involved as risk factors for developing HAM/TSP. We investigated the possible contribution of interleukin-10 (IL-10) as a risk factor to HAM/TSP by comparing frequencies of promoter region single nucleotide polymorphisms in HTLV-I infected Iranian patients who either remained asymptomatic or developed HAM/TSP and asymptomatic HTLV-I carriers. Healthy, uninfected individuals from the same region served as healthy controls. Significant differences were observed in the distribution of IL-10 promoter alleles and genotypes at position -819 and -592 between HAM/TSP patients and healthy controls (P=0.01), and between HTLV-I carriers and healthy controls (P=0.02). The frequency of the low IL-10 producer haplotype (-1082*A, -819*T, -592*A) was significantly associated with HTLV-I carriage or HAM/TSP compared with healthy controls (P=
0.02 and 0.01, respectively). Our results suggest that IL-10 -819*T and -592*A alleles are significant risk factors for developing HTLLV-I infection but do not appear to convey additional risk for developing HAM/TSP
 
کلیدواژه‌ها
Gene HAM/TSP HTLV-I IL-10 Polymorphisms
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