سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Ghelichkhani, Parisa, Yousefifard, Mahmoud, Nazemi, Lyly, Safari, Saeed, Hosseini, Mostafa, Baikpour, Masoud, Salamati Ghamsari, Samira, Yaseri, Mehdi. (1395). The Value of Serum Β-Subunit of Human Chorionic Gonadotropin Level in Prediction of Treatment Response to Methotrexate in Management of Ectopic Pregnancy; a Systematic Review and Meta-Analysis. , 4(9), 3503-3518. doi: 10.22038/ijp.2016.7409
Parisa Ghelichkhani; Mahmoud Yousefifard; Lyly Nazemi; Saeed Safari; Mostafa Hosseini; Masoud Baikpour; Samira Salamati Ghamsari; Mehdi Yaseri. "The Value of Serum Β-Subunit of Human Chorionic Gonadotropin Level in Prediction of Treatment Response to Methotrexate in Management of Ectopic Pregnancy; a Systematic Review and Meta-Analysis". , 4, 9, 1395, 3503-3518. doi: 10.22038/ijp.2016.7409
Ghelichkhani, Parisa, Yousefifard, Mahmoud, Nazemi, Lyly, Safari, Saeed, Hosseini, Mostafa, Baikpour, Masoud, Salamati Ghamsari, Samira, Yaseri, Mehdi. (1395). 'The Value of Serum Β-Subunit of Human Chorionic Gonadotropin Level in Prediction of Treatment Response to Methotrexate in Management of Ectopic Pregnancy; a Systematic Review and Meta-Analysis', , 4(9), pp. 3503-3518. doi: 10.22038/ijp.2016.7409
Ghelichkhani, Parisa, Yousefifard, Mahmoud, Nazemi, Lyly, Safari, Saeed, Hosseini, Mostafa, Baikpour, Masoud, Salamati Ghamsari, Samira, Yaseri, Mehdi. The Value of Serum Β-Subunit of Human Chorionic Gonadotropin Level in Prediction of Treatment Response to Methotrexate in Management of Ectopic Pregnancy; a Systematic Review and Meta-Analysis. , 1395; 4(9): 3503-3518. doi: 10.22038/ijp.2016.7409

The Value of Serum Β-Subunit of Human Chorionic Gonadotropin Level in Prediction of Treatment Response to Methotrexate in Management of Ectopic Pregnancy; a Systematic Review and Meta-Analysis

Journal of Pediatric Perspectives
مقاله 16، دوره 4، شماره 9 - شماره پیاپی 33، آذر 2016، صفحه 3503-3518    اصل مقاله (957.48 K)
شناسه دیجیتال (DOI): 10.22038/ijp.2016.7409
نویسندگان
Parisa Ghelichkhani1؛ Mahmoud Yousefifard2؛ Lyly Nazemi3؛ Saeed Safari4؛ Mostafa Hosseini* 5؛ Masoud Baikpour6؛ Samira Salamati Ghamsari7؛ Mehdi Yaseri7
1Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.
2Physiology Research Center and Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
3Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
4Department of Emergency Medicine, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran and Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
6Department of Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
7Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
چکیده
Background: No consensus has been reached on prognostic value of serum concentration of β (beta) subunit of human chorionic gonadotropin (β-hCG) in treatment response to methotrexate in management of ectopic pregnancy. Therefore, the present study aimed to evaluate this subject through a systematic review and meta-analysis.
Materials and Methods: An extensive literature search on online databases was performed. All studies performed on ectopic pregnancy patients treated by methotrexate from all age groups were included. After collecting data, random effect models were used to calculate the pooled standardized mean difference (SMD) of β-hCG level in treatment success and treatment failure groups. Finally, pooled performance screening characteristics of serum β-hCG level were assessed in different cut offs.
Results: Finally, 51 articles were included in meta-analysis. Overall treatment success rate of methotrexate was 84% [95% confidence interval (CI): 84-85 percent]. A negative association was found between serum β-hCG level and the treatment response before intervention (SMD= -1.10, 95% CI: -1.39 to -0.88). In addition, pooled sensitivity, specificity, and prognostic odds ratio of β-hCG in the 2000 mIU/mL cut off were: 0.75 (0.65-0.82), 0.68 (0.58-0.82), and 6.0 (5.0-8.0), respectively.
Conclusion: The present meta-analysis showed that serum β-hCG concentration before treatment could predict success of methotrexate in management of ectopic pregnancy.
کلیدواژه‌ها
Beta Subunit؛ Chorionic Gonadotropin؛ Ectopic؛ Methotrexate؛ pregnancy
آمار
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