Human T Lymphotropic Virus Type I (HTLV-I) Oncogenesis: Molecular Aspects of Virus and Host Interactions in Pathogenesis of Adult T cell Leukemia/Lymphoma (ATL) | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 2، دوره 16، شماره 3، 2013، صفحه 197-195 اصل مقاله (859.27 K) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2013.730 | ||
| نویسندگان | ||
| Sanaz Ahmadi Ghezeldasht1؛ Abbas Shirdel2؛ Mohammad Ali Assarehzadegan3؛ Tahereh Hassannia4؛ Hosian Rahimi2؛ Rahele Miri1؛ S. A. Rahim Rezaee* 5 | ||
| 1Research Centre for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Centre for Education, Culture & Research (ACECR), Mashhad Branch, Mashhad, Iran | ||
| 2Inflammation and Inflammatory diseases research Centre, Medical School, Mashhad University of Medical Science, Mashhad, Iran. | ||
| 3Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran | ||
| 4Internal Medicine Dept, Medical School, Arak University of Medical Sciences, Arak- Iran | ||
| 5Immunology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| The study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. The processes ranging from viral infection to progressing malignancy are slow and usually insufficient for establishment of transformed cells that develop cancer in only a minority of infected subjects. Therefore, viral infection is usually not the only cause of cancer, and further environmental and host factors, may be implicated. HTLV-I, in particular, is considered as an oncovirus cause of lymphoproliferative disease such as adult T cell leukemia/lymphoma (ATL) and disturbs the immune responses which results in HTLV-I associated meylopathy/tropical spastic parapresis (HAM/TSP). HTLV-I infection causes ATL in a small proportion of infected subjects (2-5%) following a prolonged incubation period (15-30 years) despite a strong adaptive immune response against the virus. Overall, these conditions offer a prospect to study the molecular basis of tumorgenicity in mammalian cells. In this review, the oncogencity of HTLV-I is being considered as an oncovirus in context of ATL. | ||
| کلیدواژهها | ||
| Adult T Cell Leukemia/Lymphoma HTLV-I Oncoviruses Oncogenecity | ||
| مراجع | ||
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