Kurt, Aysel, Tumkaya, Levent, Yuce, Suleyman, Turut, Hasan, Cumhur Cure, Medine, Sehitoglu, Ibrahim, Kalkan, Yildiray, Pusuroglu, Gokhan, Cure, Erkan. (1395). The protective effect of infliximab against carbon tetrachloride-induced acute lung injury. , 19(6), 685-691. doi: 10.22038/ijbms.2016.7138
Aysel Kurt; Levent Tumkaya; Suleyman Yuce; Hasan Turut; Medine Cumhur Cure; Ibrahim Sehitoglu; Yildiray Kalkan; Gokhan Pusuroglu; Erkan Cure. "The protective effect of infliximab against carbon tetrachloride-induced acute lung injury". , 19, 6, 1395, 685-691. doi: 10.22038/ijbms.2016.7138
Kurt, Aysel, Tumkaya, Levent, Yuce, Suleyman, Turut, Hasan, Cumhur Cure, Medine, Sehitoglu, Ibrahim, Kalkan, Yildiray, Pusuroglu, Gokhan, Cure, Erkan. (1395). 'The protective effect of infliximab against carbon tetrachloride-induced acute lung injury', , 19(6), pp. 685-691. doi: 10.22038/ijbms.2016.7138
Kurt, Aysel, Tumkaya, Levent, Yuce, Suleyman, Turut, Hasan, Cumhur Cure, Medine, Sehitoglu, Ibrahim, Kalkan, Yildiray, Pusuroglu, Gokhan, Cure, Erkan. The protective effect of infliximab against carbon tetrachloride-induced acute lung injury. , 1395; 19(6): 685-691. doi: 10.22038/ijbms.2016.7138

The protective effect of infliximab against carbon tetrachloride-induced acute lung injury

Iranian Journal of Basic Medical Sciences
مقاله 15، دوره 19، شماره 6، 2016، صفحه 685-691    اصل مقاله (1.28 M)
شناسه دیجیتال (DOI): 10.22038/ijbms.2016.7138
نویسندگان
Aysel Kurt* 1؛ Levent Tumkaya2؛ Suleyman Yuce3؛ Hasan Turut1؛ Medine Cumhur Cure4؛ Ibrahim Sehitoglu5؛ Yildiray Kalkan2؛ Gokhan Pusuroglu6؛ Erkan Cure6
1Recep Tayyip Erdogan University, School of Medicine, Department of Thoracic Surgery, Rize, Turkey
2Recep Tayyip Erdogan University, School of Medicine, Department of Histology and Embryology, Rize, Turkey
3Department of Internal Medicine, Ordu Kumru State Hospital, Ordu, Turkey
4Recep Tayyip Erdogan University, School of Medicine, Department of Biochemistry, Rize, Turkey
5Recep Tayyip Erdogan University, School of Medicine, Department of Pathology, Rize, Turkey
6Recep Tayyip Erdogan University, School of Medicine, Department of Internal Medicine, Rize, Turkey
چکیده
Objective(s): Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-α). We aimed to investigate whether Ib has a protective effect on CCl4 induced lung injury.
Materials and Methods:Rats were divided into control, CCl4, and CCl4+Ib groups. A single dose of 2 ml/kg CCI4 was administered to CCI4 group and a single dose of 7 mg/kg Ib was given to CCl4+Ib group 24 hr before applying CCI4.
Results:TNF-α, malondialdehyde (MDA), nitric oxide (NO) and caspase-3 levels of the CCl4 group were markedly higher than both the control and CCl4+Ib groups. The CCI4+Ib group had lower histopathological injury than the CCl4 group.
Conclusion:Ib as a strong TNF-α blocker decreases the production of proinflammatory cytokines, MDA, and oxidative stress leading to a protective effect against CCl4 induced lung tissue injury.
کلیدواژه‌ها
Carbon tetrachloride؛ Infliximab؛ Nitric oxide؛ Pulmonary toxicity؛ Oxidative stress
مراجع
آمار
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