The protective effect of infliximab against carbon tetrachloride-induced acute lung injury | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 15، دوره 19، شماره 6، شهریور 2016، صفحه 685-691 اصل مقاله (1.28 M) | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2016.7138 | ||
| نویسندگان | ||
| Aysel Kurt* 1؛ Levent Tumkaya2؛ Suleyman Yuce3؛ Hasan Turut1؛ Medine Cumhur Cure4؛ Ibrahim Sehitoglu5؛ Yildiray Kalkan2؛ Gokhan Pusuroglu6؛ Erkan Cure6 | ||
| 1Recep Tayyip Erdogan University, School of Medicine, Department of Thoracic Surgery, Rize, Turkey | ||
| 2Recep Tayyip Erdogan University, School of Medicine, Department of Histology and Embryology, Rize, Turkey | ||
| 3Department of Internal Medicine, Ordu Kumru State Hospital, Ordu, Turkey | ||
| 4Recep Tayyip Erdogan University, School of Medicine, Department of Biochemistry, Rize, Turkey | ||
| 5Recep Tayyip Erdogan University, School of Medicine, Department of Pathology, Rize, Turkey | ||
| 6Recep Tayyip Erdogan University, School of Medicine, Department of Internal Medicine, Rize, Turkey | ||
| چکیده | ||
| Objective(s): Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-α). We aimed to investigate whether Ib has a protective effect on CCl4 induced lung injury. Materials and Methods:Rats were divided into control, CCl4, and CCl4+Ib groups. A single dose of 2 ml/kg CCI4 was administered to CCI4 group and a single dose of 7 mg/kg Ib was given to CCl4+Ib group 24 hr before applying CCI4. Results:TNF-α, malondialdehyde (MDA), nitric oxide (NO) and caspase-3 levels of the CCl4 group were markedly higher than both the control and CCl4+Ib groups. The CCI4+Ib group had lower histopathological injury than the CCl4 group. Conclusion:Ib as a strong TNF-α blocker decreases the production of proinflammatory cytokines, MDA, and oxidative stress leading to a protective effect against CCl4 induced lung tissue injury. | ||
| کلیدواژهها | ||
| Carbon tetrachloride؛ Infliximab؛ Nitric oxide؛ Pulmonary toxicity؛ Oxidative stress | ||
| مراجع | ||
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