Effect of magnesium sulfate on hyperthermia and pentylen-tetrazol-induced seizure in developing rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 5، دوره 19، شماره 6، شهریور 2016، صفحه 608-614 اصل مقاله (965.47 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2016.7128 | ||
| نویسندگان | ||
| Maryam Ghadimkhani1؛ Ehsan Saboory* 2؛ Shiva Roshan-Milani1؛ Sedra Mohammdi1؛ Yousef Rasmi3 | ||
| 1Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran | ||
| 2Neurophysiology Research Center, Urmia University of Medical Sciences, Urmia, Iran | ||
| 3Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran | ||
| چکیده | ||
| Objective(s): Febrile seizures (FS) are the most common type of convulsive events among children. Its prevalence has been estimated to be 2-5% in children between 3 months and 5 years old. Also, blood and CSF magnesium levels have been demonstrated to be reduced in children with FS. This study investigates the effect of MgSo4 pretreatment on the behaviors caused by hyperthermia (HT) and effect of these two on pentylen-tetrazol (PTZ)-induced seizure later in life. Materials and Methods: Thirty two Wistar rats were assigned to 2 groups: saline-hyperthermia-pentylentetrazol (SHP) and magnesium-hyperthermia-pentylentetrazol (MHP). In both groups, HT was induced at the age of 18-19 days old. Before the HT, MHP group received MgSo4 and SHP group received normal saline intraperitoneally (IP). Behaviors of the rats were recorded during the HT. Then, in half of each group (n=8) at the age of 25-26 days old and in other half at the age of 78-79 days, seizure was induced by PTZ. Results: The HT successfully caused convulsive behaviors in the rats and pretreatment with MgSo4 before HT attenuated HT-induced convulsive behaviors. PTZ-induced seizures a week later was more severe than those of 2 months later. Conclusion: It can be concluded that pretreatment with MgSO4 inhibits HT-induced seizure and, in a long run, this intervention reduced PTZ-induced seizure later in life. | ||
| کلیدواژهها | ||
| Hyperthermia؛ Later in life؛ MgSO4؛ PTZ؛ Seizure | ||
| مراجع | ||
|
1. Gholipoor P, Saboory E, Roshan-Milani S, Fereidoni J. Effect of hyperthermia on histamine blood level and convulsive behavior in infant rats. Epilepsy Behav 2013; 29:269-274.
2. Dube CM, Ravizza T, Hamamura M, Zha Q, Keebaugh A, Fok K, et al. Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers. J Neurosci 2010; 30:7484-7494.
3. Dube CM, Brewster AL, Baram TZ. Febrile seizures: mechanisms and relationship to epilepsy. Brain Dev 2009; 31:366-371.
4. Dube CM, Brewster AL, Richichi C, Zha Q, Baram TZ. Fever, febrile seizures and epilepsy. Trends Neurosci 2007; 30:490-496.
5. Rajab E, Abdeen Z, Hassan Z, Alsaffar Y, Mandeel M, Al Shawaaf F, et al. Cognitive performance and convulsion risk after experimentally-induced febrile-seizures in rat. Int J Dev Neurosci 2014; 34:19-23.
6. Dube C, Richichi C, Bender RA, Chung G, Litt B, Baram TZ. Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis. Brain 2006; 129:911-922.
7. Mashimo T, Ohmori I, Ouchida M, Ohno Y, Tsurumi T, Miki T, et al. A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1.1) confers susceptibility to febrile seizures in rats. J Neurosci 2010; 30:5744-5753.
8. Vestergaard M, Wisborg K, Henriksen TB, Secher NJ, Ostergaard JR, Olsen J. Prenatal exposure to cigarettes, alcohol, and coffee and the risk for febrile seizures. Pediatrics 2005; 116:1089-1094.
9. Schuchmann S, Hauck S, Henning S, Gruters-Kieslich A, Vanhatalo S, Schmitz D, et al. Respiratory alkalosis in children with febrile seizures. Epilepsia 2011; 52:1949-1955.
10. Mazarati AM. Cytokines: a link between fever and seizures. Epilepsy Curr 2005; 5:169-170.
11. Zheng XY, Zhang HL, Luo Q, Zhu J. Kainic acid-induced neurodegenerative model: potentials and limitations. J Biomed Biotechnol 2011; 2011:457079.
12. Radzicki D, Yau HJ, Pollema-Mays SL, Mlsna L, Cho K, Koh S, et al. Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures. J Neurosci 2013; 33:9920-9931.
13. Graves RC, Oehler K, Tingle LE. Febrile seizures: risks, evaluation, and prognosis. Am Fam Physician 2012; 85:149-153.
14. Papierkowski A, Mroczkowska-Juchkiewicz A, Pawlowska-Kamieniak A, Pasternak K. [Magnesium and zinc levels in blood serum and cerebrospinal fluid in children with febrile convulsions]. Pol Merkur Lekarski 1999; 6:138-140.
15. Fawcett WJ, Haxby EJ, Male DA. Magnesium: physiology and pharmacology. Br J Anaesth 1999; 83:302-320.
16. Baram TZ, Gerth A, Schultz L. Febrile seizures: an appropriate-aged model suitable for long-term studies. Brain Res Dev Brain Res 1997; 98:265-270.
17. Hashemi P, Ebrahimi L, Saboory E, Roshan-Milani S. Effect of restraint stress during gestation on pentylenetetrazol-induced epileptic behaviors in rat offspring. Iran J Basic Med Sci 2013; 16:979-984.
18. Johnson AC, Cipolla MJ. [53-OR]: Magnesium sulfate (MgSO4) increases seizure threshold via reduced neuroinflammation in a rat model of preeclampsia. Pregnancy Hypertens 2015; 5:27.
19. Johnson AC, Tremble SM, Chan SL, Moseley J, LaMarca B, Nagle KJ, et al. Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. PLoS One 2014; 9:e113670.
20. Isler CM, Barrilleaux PS, Rinehart BK, Magann EF, Martin JN Jr. Repeat postpartum magnesium sulfate administration for seizure prophylaxis: is there a patient profile predictive of need for additional therapy? J Matern Fetal Neonatal Med. 2002; 11:75-79.
21. Hallak M, Kupsky WJ, Hotra JW, Evans JB. Fetal rat brain damage caused by maternal seizure activity: prevention by magnesium sulfate. Am J Obstet Gynecol 1999; 181:828-834. 22. Saboory E, Ahmadzadeh R, Roshan-Milani S. Prenatal exposure to restraint or predator stresses attenuates field excitatory postsynaptic potentials in infant rats. Int J Dev Neurosci 2011; 29:827-831.
23. Saboory E, Derchansky M, Ismaili M, Jahromi SS, Brull R, Carlen PL, et al. Mechanisms of morphine enhancement of spontaneous seizure activity. Anesth Analg 2007; 105:1729-1735.
24. Saboory E, Gholami M, Zare S, Roshan-Milani S. The long-term effects of neonatal morphine administration on the pentylenetetrazol seizure model in rats: the role of hippocampal cholinergic receptors in adulthood. Dev Psychobiol 2014; 56:498-509.
25. Rowley HL, Martin KF, Marsden CA. Decreased GABA release following tonic-clonic seizures is associated with an increase in extracellular glutamate in rat hippocampus in vivo. Neuroscience 1995; 68:415-422.
26. Klioueva IA, van Luijtelaar EL, Chepurnova NE, Chepurnov SA. PTZ-induced seizures in rats: effects of age and strain. Physiol Behav 2001; 72:421-426.
27. Ebrahimi L, Saboory E, Roshan-Milani S, Hashemi P. Effect of prenatal forced-swim stress and morphine co-administration on penty-lentetrazol-induced epileptic behaviors in infant and prepubertal rats. Dev Psychobiol 2014; 56:1179-1186.
28. Gholami M, Saboory E. Morphine exposure induces age-dependent alterations in pentyl-enetetrazole-induced epileptic behaviors in prepubertal rats. Dev Psychobiol 2013; 55:881-887.
29. Saboory E, Ebrahimi L, Roshan-Milani S, Hashemi P. Interaction of prenatal stress and morphine alters prolactin and seizure in rat pups. Physiol Behav. 2015;149:181-6.
30. Kristian T, Siesjo BK. Calcium in ischemic cell death. Stroke. 1998;29(3):705-18.
31. Domachevsky L, Pick CG, Arieli Y, Krinsky N, Abramovich A, Eynan M. Do hyperbaric oxygen-induced seizures cause brain damage? Epilepsy Res 2012; 100:37-41.
32. Meldrum BS. First Alfred Meyer Memorial Lecture. Epileptic brain damage: a consequence and a cause of seizures. Neuropathol Appl Neurobiol 1997; 23:185-201.
33. Holmes GL. Do seizures cause brain damage? Epilepsia 1991; 32:S14-28. | ||
|
آمار تعداد مشاهده مقاله: 920 تعداد دریافت فایل اصل مقاله: 846 |
||