Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 9، دوره 7، شماره 1، فروردین و اردیبهشت 2017، صفحه 73-79 اصل مقاله (494.21 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2016.7073 | ||
| نویسندگان | ||
| Niloofar Kahkeshani1؛ Milad Gharedaghi1؛ Abbas Hadjiakhoondi2؛ Mohammad Sharifzadeh3؛ Mahnaz Khanavi* 4 | ||
| 1Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research center, Tehran University of Medical Sciences, Tehran, Iran | ||
| 2Departments of Pharmacognosy and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran | ||
| 3Departments of Pharmacology and Toxicology and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran | ||
| 4Faculty of Land and Food Systems, University of British Columbia, B.C., Canada | ||
| چکیده | ||
Objective: The genus Marrubium is used for treatment of joint pain, gout, stomach-ache and colic in Iranian Traditional Medicine. Marrubium astracanicum Jacq. (M. astracanicum) is a native species in the flora of Iran. The aim of this study was to evaluate the antinociceptive properties of various extracts of aerial parts of M. astracanicum. Materials and Methods: Antinociceptive activities of total hydroalcoholic extract (THE) and its n-hexane (non-polar) and residual partition (polar) fractions were analyzed using formalin test in mice. Morphine (5 mg/kg) and normal saline were used as positive and negative controls, respectively. Results: Intraperitoneal administration of THE (50, 100 and 200 mg/kg), non-polar fraction (200 mg/kg) and polar fraction (100 and 200 mg/kg), 30 min before formalin injection, caused significant analgesic activity in acute phase (0-5 min after formalin injection) of formalin test (p0.05 in comparison with morphine). In chronic phase (15–60 min after formalin injection), non-polar and polar fractions (50, 100 and 200 mg/kg) showed significant analgesic activity (p0.05 in comparison with morphine). Conclusion: Different extracts of M. astracanicum demonstrated antinociceptive activity that support the traditional usage of Marrubium genus for the treatment of arthritis, gout and other inflammatory diseases. | ||
| کلیدواژهها | ||
| Marrubium astracanicum؛ Pain measurment؛ Analgesic | ||
| مراجع | ||
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