Layegh, Pouran, Mosallaei, Navid, Bagheri, Danial, Jaafari, Mahmoud Reza, Golmohammadzadeh, Shiva. (1392). The efficacy of Isotretinoin-loaded solid lipid nanoparticles in comparison to Isotrex® on acne treatment. , 1(1), 38-47. doi: 10.7508/nmj.2013.01.005
Pouran Layegh; Navid Mosallaei; Danial Bagheri; Mahmoud Reza Jaafari; Shiva Golmohammadzadeh. "The efficacy of Isotretinoin-loaded solid lipid nanoparticles in comparison to Isotrex® on acne treatment". , 1, 1, 1392, 38-47. doi: 10.7508/nmj.2013.01.005
Layegh, Pouran, Mosallaei, Navid, Bagheri, Danial, Jaafari, Mahmoud Reza, Golmohammadzadeh, Shiva. (1392). 'The efficacy of Isotretinoin-loaded solid lipid nanoparticles in comparison to Isotrex® on acne treatment', , 1(1), pp. 38-47. doi: 10.7508/nmj.2013.01.005
Layegh, Pouran, Mosallaei, Navid, Bagheri, Danial, Jaafari, Mahmoud Reza, Golmohammadzadeh, Shiva. The efficacy of Isotretinoin-loaded solid lipid nanoparticles in comparison to Isotrex® on acne treatment. , 1392; 1(1): 38-47. doi: 10.7508/nmj.2013.01.005

The efficacy of Isotretinoin-loaded solid lipid nanoparticles in comparison to Isotrex® on acne treatment

Nanomedicine Journal
مقاله 5، دوره 1، شماره 1، 2013، صفحه 38-47    اصل مقاله (617.82 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.7508/nmj.2013.01.005
نویسندگان
Pouran Layegh1؛ Navid Mosallaei2؛ Danial Bagheri2؛ Mahmoud Reza Jaafari3؛ Shiva Golmohammadzadeh* 3
1Research Center for Cutaneous Leishmaniasis, Department of Dermatology, Mashhad University of Medical Sciences, Mashhad, Iran
2School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Topical retinoids are considered as the first line therapy in the treatment of acne vulgaris, but they are associated with cutaneous irritation. In this study, isotretinoin-loaded solid lipid nanoparticles(IT-SLN) were prepared to treat the mild to moderate acne. Also using IT-SLN would minimize IT adverse effects in comparison to commercial product, Isotrex®.
This study was conducted to prepare and characterize IT-SLN and assessing the efficiency of IT-SLN comparing to Isotrex® acne.
IT-SLN was prepared using hot high pressure homogenization method.  IT-SLN contained 0.05% IT in 5% of lipid phase (Glyceryl monostearate- GMS) and tween 80 (2.5 % w/v) was used as surfactant in the aqueous phase. IT-SLN was characterized by particle size analyzing, differential scanning calorimetry and transmission electron microscopy. Encapsulation efficacy was also obtained using spectrophotometry. The efficacy of IT-SLN was evaluated in a randomized, single-blind, parallel-group study and compared with Isotrex®. Forty patients encountered in the study and divided in two groups. Treatment regimen was once-nightly topical administration accompanied with topical administration of clindamycin 2% solution twice a day for 8 weeks.
The particle size of IT-SLN was around 60 nm with PDI of 0.4 and zeta potential was about -40 mV. Encapsulation efficacy of IT in SLN in crystalline form was 84±0.21%. IT-SLN produced significantly better treatment than Isotrex® in both non-inflammatory and inflammatory lesions according to its recovery percent after 8 weeks. Also IT-SLN gained better global assessment scores.
Our results showed that IT-SLN had higher efficacy than Isotrex® to clear non-inflammatory and inflammatory lesions.
کلیدواژه‌ها
Solid lipid nanoparticles (SLN)؛ Isotretinoin؛ Acne؛ Clinical trial
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