Antinociceptive action of Vanillosmopsis arborea in male mice | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 154، دوره 7، شماره 1، فروردین و اردیبهشت 2017، صفحه 93-98 اصل مقاله (400.34 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2016.6956 | ||
| نویسندگان | ||
| Laura Inocencio Leite* 1؛ Gerlânia de Oliveira Leite2؛ Bruno Anderson Fernandes Silva3؛ Severino Denício Gonçalves Sousa3؛ Thales Coutinho3؛ Renata Sampaio3؛ Irwin Menezes3؛ José Galberto Martins Costa3؛ Adriana Campos4 | ||
| 1Department of Biology at the Federal University of Cariri, Brejo Santo – CE, Brazil | ||
| 2Department of Pharmacology, University of Santa Maria, Santa Maria- RS, Brazil | ||
| 3Department of Chemical Biological at the Regional University of Cariri, Crato – CE, Brazil | ||
| 4Department of Fharmacology at the University of Fortaleza, Fortaleza – CE, Brazil | ||
| چکیده | ||
Objective: Vanillosmopsis arborea Baker (Asteraceae) has high economic value from Chapada to Araripe and its bark essential oil is a potential source of alpha-bisabolol. The present study aimed to elucidate the antinociceptive and antipruritic properties of the essential oil of V. arborea Baker (EOVA) in mice. Materials and Methods: The antinociceptive activity was assessed using the capsaicin, glutamate, hot plate and cold allodynia tests. The antipuritic effects were also verified based on histamine-induced scratching behavior. Results: EOVA reduced the paw licking induced by capsaicin, but not that induced by glutamate. The essential oil increased the latency time in the hot plate, attenuated the cold allodynia induced by acetone and inhibited histamine-induced scratching behavior. Conclusion: The experimental data demonstrated that EOVA showed central and peripheral antinociceptive activity and antipruritic effect. | ||
| کلیدواژهها | ||
| Vanillosmopsis arborea؛ Essential oil؛ Antinociceptive؛ Antipruritic | ||
| مراجع | ||
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