Anti-inflammatory effect of Fumaria parviflora leaves based on TNF-α, IL-1, IL-6 and antioxidant potential | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 5، دوره 7، شماره 1، فروردین و اردیبهشت 2017، صفحه 37-45 اصل مقاله (590.2 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2016.6955 | ||
| نویسندگان | ||
| Waseem Rizvi* 1؛ Mohammad Fayazuddin2؛ Ompal Singh3؛ Shariq Naeem1؛ Shagufta Moin4؛ Kafil Akhtar5؛ Anil Kumar1 | ||
| 1Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh 202002, India | ||
| 2Department of Pharmacology, Raichur Institute of Medical Sciences, Raichur, 584101, India | ||
| 3Chemical Research Unit, Department of research in Unani Medicine, Aligarh Muslim University, Aligarh 202002, India | ||
| 4Department of Biochemistry, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh 202002, India | ||
| 5Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh 202002, India | ||
| چکیده | ||
Objective: In this study, we evaluated anti-inflammatory activity of leaves of Fumaria parviflora (F. parviflora) and underlying mechanisms by using in vivo models of inflammation. Material and Methods: Albino Wistar rats of either sex weighing 150 - 200 g were used. Soxhlet ethanol and aqueous extracts of leaves of F. parviflora (EFP and AFP) were prepared. The anti-inflammatory activity was studied using carrageenan-induced paw edema method and cotton pellet granuloma method. Levels of cytokines such as TNF-α, IL-6 and IL-1 and activity of antioxidant enzymes including catalase (CAT) and glutathione peroxidase (GPx) were estimated. Results: Leaves of F. parviflora demonstrated significant (p<0.001) decrease in paw edema in carrageenan-induced paw edema method. It diminished the serum tumour necrosis factor-α (TNF-α), IL-6 and IL-1 levels and also significantly attenuated the malondialdehyde (MDA) levels. The activity of CAT and GPx was increased in paw tissue. It also demonstrated significant decrease in granuloma formation in cotton pellet-induced granuloma method. Conclusion: Leaves of F. parviflora possess anti-inflammatory activity as they inhibit various cytokines and have antioxidant effects and free radical scavenging activity. | ||
| کلیدواژهها | ||
| Fumeria؛ Carrageenan؛ Cytokines؛ Antioxidant؛ Anti-inflammatory | ||
| مراجع | ||
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