Rheum turkestanicum rhizomes possess anti-hypertriglyceridemic, but not hypoglycemic or hepatoprotective effect in experimental diabetes | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 1، دوره 7، شماره 1، فروردین و اردیبهشت 2017، صفحه 1-9 اصل مقاله (575.09 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2016.6920 | ||
| نویسندگان | ||
| Mousa-Al-Reza Hadjzadeh1؛ Ziba Rajaei* 2؛ Esmaeil Khodaei3؛ Maryam Malek2؛ Habib Ghanbari4 | ||
| 1Neurocognitive Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| 3Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 4Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
Objective: Rheum turkestanicum (R. turkestanicum) rhizomes have been used in Iranain traditional medicine as an anti-diabetic agent. The purpose of the present investigation was to evaluate the anti-diabetic and antioxidant activities of R. turkestanicum rhizome extract in streptozotocin-induced diabetic rats. Materials and Methods: Diabetes was induced by a single intraperitoneal injection of 55 mg/kg streptozotocin in male Wistar rats. Diabetic rats received the decoction extract of R. turkestanicum rhizomes at the doses of 200, 400 and 600 mg/kg daily by gavage for 3 weeks. Serum glucose and lipid levels were measured in all groups before diabetes induction and at the end of week 3. Oxidative stress was evaluated in the liver by measurement of malondialdehyde levels and total thiol concentration at the end of the experiment. Results: A significant increase in serum glucose and triglyceride levels was observed in diabetic rats, which was accompanied by increased malondialdehyde levels and decreased total thiol concentration in the liver after 3 weeks. Treatment of diabetic rats with R. turkestanicum rhizome extract at the doses of 200, 400 and 600 mg/kg over a 3-week period did not change serum glucose, hepatic malondialdehyde and total thiol levels in diabetic rats. However, treatment with R. turkestanicum extract significantly decreased serum triglyceride levels in a dose-dependent manner at the end of the experiment. Conclusion: R. turkestanicum rhizome extract possess anti-hypertriglyceridemic, but not hypoglycemic or hepatoprotective effect in diabetic rats. Therefore, R. turkestanicum rhizome should be consumed with more caution by diabetic patients. | ||
| کلیدواژهها | ||
| Rheum turkestanicum؛ Diabetes Mellitus؛ Hyperglycemia؛ Hypertriglyceridemia؛ Oxidative stress | ||
| مراجع | ||
|
Adeghate E, Ponery A. 2002. GABA in the endocrine pancreas: cellular localization and function in normal and diabetic rats. Tissue Cell, 34: 1-6.
Andic S, Tuncturk Y, Ocak E, Kose S. 2009. Some chemical characteristics of edible wild Rhubarb species (Rheum Ribes L.). Res J Agr Biol Sci, 5: 973-977.
Anila L, Vijayalakshmi NR. 2002. Flavonoids from Emblica officinalis and Mangifera indica: effectiveness for dyslipidemia. J Ethnopharmacol, 79: 81–87.
Arulselvan P, Subramanian SP. 2007. Beneficial effects of Murraya koenigii leaves on antioxidant defense system and ultrastructural changes of pancreatic β-cells in experimental diabetes in rats. Chem Biol Interact, 165: 155–164.
Balasubashini MS, Rukkumani R, Viswanathan P, Venugopal PM. 2004. Ferulic acid alleviates lipid peroxidation in diabetic rats. Phytother Res, 18: 310–314.
Bansal P, Paula P, Mudgal J, Nayak PG, Pannakal ST, Priyadarsini KI, Unnikrishnan MK. 2012. Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice. Exp Toxicol Pathol, 64: 651– 658.
Chen ZQ, Wang JJ. 2010. Hypoglycemic and antioxidant effects of Rheum franzenbachii extract in streptozotocin-induced diabetic rats. Pharm Biol, 48: 703-707.
Coskun O, Kanter M, Korkmaz A, Oter S. 2005. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and ß-cell damage in rat pancreas. Pharmacol Res, 51: 117–123.
Ellman GL. 1959. Tissue sulfhydryl groups. Arch Biochem Biophys, 82: 70–77.
Goel V, Ooraikul B, Basu TK. 1997. Cholesterol lowering effects of rhubarb fibre in hypercholesterolemic men. J Am Coll Nutr, 16: 600–604.
Hadjzadeh MA, Rajaei Z, Moradi R, Ghorbani A. 2015. Effects of hydroalcoholic extract of watercress (Nasturtium officinale) leaves on serum glucose and lipid levels in diabetic rats. Indian J Physiol Pharmacol, 59: 223-230.
Hadjzadeh MA, Rajaei Z, Keshavarzi Z, GhasemShirazi M, Toosi V. 2013. Effect of aqueous extract of Rheum ribes on cisplatin induced nephrotoxicity in rat. J Pharm Bioallied Sci, 5: 80-84.
Hadjzadeh MA, Parsaee H, Sadeghian A. 2004. Cholesterol lowering effect of Rheum ribes in hypercholesterolemic rabbits. Med J Islam Repub Iran, 18: 277–280.
Hu R, Lu Y, Dai X, Pan Y. 2010. Screening of antioxidant phenolic compounds in Chinese Rhubarb combining fast counter-current chromatography fractionation and liquid chromatography/mass spectrometry analysis. J Sep Sci, 33: 1595-1603.
Kakkar R, Mantha SV, Radhi J, Prasad K, Kalra J. 1998. Increased oxidative stress in rat liver and pancreas during progression of streptozotocin-induced diabetes. J Clin Sci, 94: 623–632.
Kumar V, Ahmed D, Gupta PS, Anwar F, Mujeeb M. 2013. Anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of Melastoma malabathricum Linn. Leaves in streptozotocin induced diabetic rats. BMC Complement Alternat Med, 13: 222.
Kuzuya T, Nakagawa S, Satoh J, Kanazawa Y, Iwamoto Y, Kobayashi M, et al. 2002. Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. Diabetes Res Clin Pract, 55: 65–85.
Maiese K. 2015. New insights for oxidative stress and diabetes mellitus. Oxid Med Cell Longev, 875961.
Ozbek H, Ceylan E, Kara M, Ozgokce F, Koyuncu M. 2004. Hypoglycemic effect of Rheum ribes roots in alloxan induced diabetic and normal mice. Scand J Lab Anim Sci, 2: 113-115.
Ozkaya D, Naziroglu M, Armagan A, Demirel A, Koroglu BK, Colakoglu N, et al. 2011. Dietary vitamin C and E modulates oxidative stress induced-kidney and lens injury in diabetic aged male rats through modulating glucose homeostasis and antioxidant systems. Cell Biochem Funct, 29: 287–293.
Ozturk M, Aydogmus-Ozturk F, Duru ME, Topcu G. 2007. Antioxidant activity of stem and root extracts of Rhubarb (Rheum ribes): An edible medicinal plant. Food Chem, 103: 623–630.
Radhika R, Krishnakumar I, Sudarsanam D. 2010. Antidiabetic activity of Rheum emodi in alloxan induced diabetic rats. Int J Pharm Sci Res, 8: 296-300.
Rajaei Z, Hadjzadeh MA, Moradi R, Ghorbani A, Saghebi A. 2015. Antihyperglycemic and antihyperlipidemic effects of hydroalcoholic extract of Securigera securidaca seeds in streptozotocin-induced diabetic rats. Adv Biomed Res, 30: 4: 33.
Rajaei Z, Hadjzadeh MA, Nemati M, Hosseini M, Ahmadi M, Shafiee S. 2013. Antihyperglycemic and antioxidant activity of crocin in streptozotocin-induced diabetic rats. J Med Food, 16: 206-210.
Saltiel AR, Kahn CR. 2001. Insulin signalling and the regulation of glucose and lipid metabolism. Nature, 414: 799–806.
Sharma I, Aaradhya M, Kodikonda M, Naik PR. 2015. Antihyperglycemic, antihyperlipidemic and antioxidant activity of phenolic rich extract of Brassica oleraceae vargongylodes on streptozotocin induced Wistar rats. Springer Plus, 4: 212.
Sharma JB, Sharma A, Bahadur A, Vimala N, Satyam A, Mittal S. 2006. Oxidative stress markers and antioxidant levels in normal pregnancy and pre-eclampsia. Int J Gynaecol Obstet, 94: 23–27.
Sharma SR, Dwivedi SK, Swarup D. 1997. Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of Caesalpinia bonducella seeds in rats. J Ethnopharmacol, 58: 39–44.
Shiezadeh F, Mousavi SH, Amiri MS, Iranshahi M, Tayarani-Najaran Z, Karimi G. 2013. Cytotoxic and apoptotic potential of Rheum turkestanicum Janisch root extract on human cancer and normal cells. Iran J Pharm Res, 12: 811-819.
Spinas GA. 1999. The dual role of nitric oxide in islet 𝛽-cells. News Physiol Sci, 14: 49–54.
Szkudelski T. 2001. The mechanism of alloxan and streptozotocin action in ß cells of the rat pancreas. Physiol Res, 50: 536–546.
Taskinen MR. 1987. Lipoprotein lipase in diabetes. Diabetes Metabol, 3: 551–570.
Upendra M, Sreenivasulu M, Chengaiah B. 2010. Micro-vascular and macro-vascular complication of diabetes mellitus. IJPRIF, 2: 1883–1892.
Xue J, Ding W, Liu Y. 2010. Anti-diabetic effects of emodin involved in the activation of PPAR gamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice. Fitoterapia, 81: 173-177.
Zhang H, Liu M. 2004. Separation procedures for the pharmacologically active components of rhubarb. J Chromatogr B, 812: 175–181. | ||
|
آمار تعداد مشاهده مقاله: 22,548 تعداد دریافت فایل اصل مقاله: 6,765 |
||