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Chowdhary, Rashmi, Khan, Roji, Bhatt, Girish, Malik, Yash, Malik, Rajesh, Goel, Sudhir. (1395). Projection of Need for Pathogenetic Testing for Mitochondrial Dysfunction in Autistic Spectrum Disorder (ASD) Children of India. , 4(6), 1877-1883. doi: 10.22038/ijp.2016.6893
Rashmi Chowdhary; Roji Khan; Girish Bhatt; Yash Malik; Rajesh Malik; Sudhir Goel. "Projection of Need for Pathogenetic Testing for Mitochondrial Dysfunction in Autistic Spectrum Disorder (ASD) Children of India". , 4, 6, 1395, 1877-1883. doi: 10.22038/ijp.2016.6893
Chowdhary, Rashmi, Khan, Roji, Bhatt, Girish, Malik, Yash, Malik, Rajesh, Goel, Sudhir. (1395). 'Projection of Need for Pathogenetic Testing for Mitochondrial Dysfunction in Autistic Spectrum Disorder (ASD) Children of India', , 4(6), pp. 1877-1883. doi: 10.22038/ijp.2016.6893
Chowdhary, Rashmi, Khan, Roji, Bhatt, Girish, Malik, Yash, Malik, Rajesh, Goel, Sudhir. Projection of Need for Pathogenetic Testing for Mitochondrial Dysfunction in Autistic Spectrum Disorder (ASD) Children of India. , 1395; 4(6): 1877-1883. doi: 10.22038/ijp.2016.6893

Projection of Need for Pathogenetic Testing for Mitochondrial Dysfunction in Autistic Spectrum Disorder (ASD) Children of India

Journal of Pediatric Perspectives
مقاله 8، دوره 4، شماره 6 - شماره پیاپی 30، شهریور 2016، صفحه 1877-1883    اصل مقاله (561.26 K)
شناسه دیجیتال (DOI): 10.22038/ijp.2016.6893
نویسندگان
Rashmi Chowdhary* 1؛ Roji Khan2؛ Girish Bhatt3؛ Yash Malik4؛ Rajesh Malik5؛ Sudhir Goel6
1Assistant Professor Biochemistry AIIMS Bhopal, India.
2Junior Research Fellow, Department of Biochemistry, AIIMS Bhopal, India.
3Assistant Professor, Department of Pediatrics, AIIMS Bhopal, India.
4MBBS Student, AIIMS Bhopal, India.
5Professor, Head, Department of Radiodiagnosis, AIIMS Bhopal, India.
6Professor, Head, Department of Biochemistry, AIIMS Bhopal, India.
چکیده
Background
 Autistic Spectrum Disorder (ASD) is a neurodevelopmental disorder. There is a large quantity of evidence which point towards a positive correlation between Autism and Mitochondrial disorders (MD). In addition to that, several published reports, indicate that people with neurological disorders exhibit pathological signs of mitochondrial disorders and vice versa. Screening for underlying MD is essential in ASD as the children (clinically) appear and behave the same way in the both instances; however, their management is very different.
Materials and Methods
The current study examined biochemical, neuroimaging and genotyping technique in ASD patients to see which technique would be easier to interpret and indicate underlying MD. The analysis of the screening was based on several objectives like clinical, histological, biochemical, molecular, neuroimaging and enzymatic findings.
Results
We found out that pathogenetic analysis based on clinical and genotyping gives spontaneous results to analyse the possibility of MD in ASD patients.
Conclusion
 It does not necessarily require blood samples from ASD patients to accomplish this type of analysis.     
کلیدواژه‌ها
Autistic Spectrum Disorder؛ Children؛ Mitochondrial DNA
آمار
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