The effect of spinally administered WIN 55,212-2, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 8، دوره 19، شماره 4، تیر 2016، صفحه 394-401 اصل مقاله (498.52 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2016.6811 | ||
| نویسندگان | ||
| Samane Jahanabadi1، 2؛ Mohamad Reza Hadian3؛ Javad Shamsaee1؛ Seyed Mohammad Tavangar4؛ Alireza Abdollahi4؛ Ahmadreza Dehpour1، 5؛ Shahram Ejtemaei Mehr* 1، 5 | ||
| 1Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| 2Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 3Department of Physical Therapy, Faculty of Rehabilitation Sciences, Tehran University of Medical Sciences, Tehran, Iran | ||
| 4Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| 5Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Objective(s):Diabetic neuropathy (DN) is a common complication of diabetes that leads to allodynia, impaired nerve conduction, and progressive sensory loss. The aim of this study was to observe the effect of a high-affinity cannabinoid receptors agonist, WIN 55,212-2, on thermal hyperalgesia, nerve conduction velocity and sciatic nerve histopathology in diabetic rats. Materials and Methods: Diabetes was induced in rats using a single dose of streptozotocin (45 mg/kg IP). Results: Intrathecal (IT) administration of WIN55, 212-2 (1, 10, 100 µg/10 µl, IT), produced antinociceptive effects in the hot plate test and also improved nerve conduction velocity (100 µg/10 µl, IT) and sciatic nerve histology. Conclusion: These data show that cannabinoids have potent antinociceptive effects through direct actions in the spinal dorsal horn of nociceptive pathway. This suggests that intrathecally administered cannabinoids may offer hopeful strategies for the treatment of diabetic neuropathic pain. | ||
| کلیدواژهها | ||
| Diabetes؛ Intrathecal؛ Neuropathy؛ Pain؛ WIN 55؛ 212-2 | ||
| مراجع | ||
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