Preparation and evaluation of electrospun nanofibers containing pectin and time-dependent polymers aimed for colonic drug delivery of celecoxib | ||
| Nanomedicine Journal | ||
| مقاله 5، دوره 3، شماره 1، 2016، صفحه 43-48 اصل مقاله (911.67 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.7508/nmj.2016.01.005 | ||
| نویسندگان | ||
| A. Akhgari* 1، 2؛ M. Hossein Rotubati2 | ||
| 1Nanotechnology Research Center , School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran | ||
| 2Targeted Drug Delivery Research Center, School of Pharmauy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective(s):The aim of this study was to prepare electrospun nanofibers of celecoxib using combination of time-dependent polymers with pectin to achieve a colon-specific drug delivery system for celecoxib. Materials and Methods:Formulations were produced based on two multilevel 22 full factorial designs. The independent variables were the ratio of drug:time-dependent polymer (X1) and the amount of pectin in formulations (X2). Electrospinning process was used for preparation of nanofibers. The spinning solutions were loaded in 5 mL syringes. The feeding rate was fixed by a syringe pump at 2.0 mL/h and a high voltage supply at range 10-18 kV was applied for electrospinning. Electrospun nanofibers were collected and evaluated by scanning electron microscopy and drug release in the acid and buffer with pH 6.8 with and without pectinase. Results:Electrospun nanofibers of celecoxib with appropriate morphological properties were produced via electrospinning process. Drug release from electrospun nanofibers was very low in the acidic media; while, drug release in the simulated colonic media was the highest from formulations containing pectin. Conclusion: Formulation F2 (containing drug:ERS with the ratio of 1:2 and 10% pectin) exhibited acceptable morphological characteristics and protection of drug in the upper GI tract and could be a good candidate as a colonic drug delivery system for celecoxib. | ||
| کلیدواژهها | ||
| Celecoxib؛ Colonic delivery؛ Electrospinning؛ Nanofiber؛ Pectin | ||
| مراجع | ||
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