Effects of berberine on acquisition and reinstatement of morphine-induced conditioned place preference in mice | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 7، دوره 6، شماره 2، خرداد و تیر 2016، صفحه 198-204 اصل مقاله (461.46 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2016.5209 | ||
| نویسندگان | ||
| Faezeh Vahdati Hassani1؛ Mahmoud Hashemzaei2؛ Edris Akbari1؛ Mohsen Imenshahidi1؛ Hossein Hosseinzadeh* 3 | ||
| 1School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Department of Pharmacology and Toxicology, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran | ||
| 3Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective: It has been shown that berberine, a major component of Berberis vulgaris extract, modulates the activity of several neurotransmitter systems including dopamine (Da) and N-methyl-D-aspartate (NMDA) contributing to rewarding and reinforcing effects of morphine. Drug craving and relapsing even after a long time of abstinence therapy are the most important problems of addiction. In the present study, we investigated the alleviating effects of berberine on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) in mice. Materials and Methods: In male NMRI mice, the acquisition of CPP was established by 40 mg/kg of morphine sulphate injection and extinguished after the extinction training and reinstated by a 10 mg/kg injection of morphine. The effects of different doses of berberine (5, 10, and 20 mg/kg) on the acquisition and reinstatement induced by morphine were evaluated in a conditioned place preference test. Results: The results showed that intraperitoneal administration of berberine (5, 10, and 20 mg/kg) did not induce conditioned appetitive or aversive effects. Injection of berberine (10 and 20 mg/kg) 2 h before the morphine administration reduced acquisition of morphine-induced CPP. In addition, same doses of berberine significantly prevented the reinstatement of morphine-induced CPP. Conclusion: These results suggest that berberine can reduce the acquisition and reinstatement of morphine-induced conditioned place preference and may be useful in treatment of morphine addiction. | ||
| کلیدواژهها | ||
| Berberis vulgaris؛ Berberine؛ Conditioned place preference؛ Morphine؛ Mouse | ||
| مراجع | ||
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